Pentosan injection bruising, is this normal or am I injecting wrong

Posted by grinder265 in Safety & Side Effects - 1 points, 0 comments.

Been running pentosan for about 3 weeks now for some knee cartilage issues that kept flaring up during training. 2mg/kg weekly subcutaneous like the vet dosing extrapolation suggests. The stuff works pretty well honestly, my knee feels less crunchy on long runs.

Ngl though im getting some decent bruising at the injection site almost every time. Like yellowish patches that stick around for a few days. Not huge but noticeable. I rotate injection sites to my love handles and upper butt but still getting them.

Im a pharmacist so I know pentosan has mild anticoagulant properties but this seems a bit much for just that. Has anyone else experienced this? Wondering if I should be concerned about cumulative bleeding risk especially since I run ultramarathons and take ibuprofen occasionally after races. I know mixing NSAIDs with anticoagulant activity is generally not ideal but I figured the topical diclofenac I use on my ankle is pretty systemic-sparing.

Should I just push through it or get some bloodwork done to check coagulation times? Kind of a pain to explain to my doctor why I need it checked.

Community discussion - research and educational context only. Not medical advice.