TB-500 alongside BPC for a lingering rotator cuff, anyone run that combo?

Question

I am about 6 months into a partial supraspinatus tear that PT alone is not really getting across the finish line. Progress has slowed to almost nothing the last month and my therapist is talking about a second MRI if nothing changes by spring. Anectdotally I keep seeing people pair TB-500 with BPC-157 for tendon stuff. The idea seems to be BPC handles local inflammation and tendon remodeling while TB-500 helps with cell migration and blood supply more systemically. That tracks with what the profile pages describe too, actin upregulation and angiogenesis on the TB side. For those who have actually run both together, how did you time them around your loading phases? Did you run BPC daily and TB-500 twice a week like the typical loading schedule, or stagger them differently? And did you notice anything at the joint itself, or was it more of a general recovery feel? Trying to figure out if this is worth bringing up with my PT or just keeping it in my back pocket.

frugalmira · Accepted Answer

Got into peptides for similar reasons, weight loss that made me look into recovery stuff. For my rotator cuff issue I ended up just doing BPC locally around the joint and it was enough to get me past a plateau, no TB added. The actin sequestration idea with TB is interesting on paper, but tendon healing really comes down to load management and blood flow over time, not just molecules. If PT has stalled, the problem might be the loading program itself, not the missing peptide. I would bring it up with your PT, not as "I want to add TB" but more like "what can we change in the loading to break this stall." A second MRI sounds reasonable if you have truly plateaued, tendons can hide partial tears that don't show well early on. Worth noting that any real systemic effect from TB takes weeks to show up, so if you try it, give it actual time before judging.

tracker_jade · Answer

Appreciate that, and yeah the loading program point is probably the fairest hit. My PT has me on heavy isometric holds and slow eccentrics but we have not really changed anything in a while, maybe that is the actual bottleneck. Anectdotally when I added BPC alone last round I felt some change at the joint itself within a few weeks, which is why I was eyeing TB to stack on top. Did you keep BPC oral or inject it locally around the cuff, and how long before you noticed the plateau break?

TB-500 alongside BPC for a lingering rotator cuff, anyone run that combo?

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