New senolytic approach looks clever but human proof still missing
Posted by vik_trains in Longevity & Anti-Aging - 0 points, 0 comments.
This Imperial College London piece reports on a Nature Cell Biology study where they screened over 10,000 electrophilic compounds to find molecules that kill senescent cells while sparing healthy ones. It’s a lab‑based discovery that highlights a specific metabolic weakness in ageing cells.
For me it’s an interesting step forward but I’m cautious about getting excited too soon. The data are still in cells and mice, and we’ve seen many promising senolytics fail to translate to real‑world benefits or bring unexpected side effects. My own limited experience with rapamycin has taught me that early‑stage results often look cleaner than what happens in a human body.
What do others think about the chances of these electrophilic senolytics making it to clinical trials? Have any of you seen early human data on similar electrophilic drugs, or should we wait for more animal safety work before getting hopeful?
Community discussion - research and educational context only. Not medical advice.