Curious about GlyNAC vs just taking NAC alone, what is the point of the glycine

Posted by rachel61 in Longevity & Anti-Aging - 1 points, 2 comments.

Ok so ive been digging into the longevity stuff for a while now and rapamycin has been my main thing, but i keep seeing GlyNAC pop up in the research and i finally sat down and read more about it.

The part that gets me is that it is basically just glycine plus NAC, two cheap amino acids. NAC i get, it is a precursor for glutathione and i know glutathione matters for detox and oxidation. But why do you need the glycine too? I thought NAC alone should cover the cysteine part and your body makes glycine on its own fine.

For what it is worth, the studies in older folks sounded pretty wild to me, mitochondrial improvements, strength, cognition, the works. But i am skeptical until i understand the mechanism better.

Has anyone here tried the combo? And did you actually feel a difference compared to just NAC by itself? I am not looking to jump on a bunch of stacks at once but this one seems simple enough that it might be worth a trial run if the science holds up.

Comments

• researcher_daily806: The glycine matters because your body actually struggles to make enough of it as you get older, even if technically it can synthesize it. Cysteine tends to be the rate limiting amino acid for glutathione, but if glycine is short too then youre not getting full glutathione production no matter how much NAC you take. That is the whole rationale behind the combo from what ive read. I tried just NAC for a few months first and didnt really notice much. Added glycine and within a couple weeks my slee
• rachel61: That actually makes sense about glycine becoming harder to make as you age, i didnt think about that part. I know nac on its own never did much for me either so maybe i was missing half the equation the whole time. How much glycine did you pair with it, like a 1:1 ratio?

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