Tesamorelin long‑term data – does the fat loss stick after you stop?

Posted by fasted_scientist in GH & Growth Peptides - 1 points, 0 comments.

https://www.natap.org/2008/HIV/082908_02.htm

This is a 52‑week safety and efficacy study of tesamorelin in HIV patients with abdominal fat accumulation. It reports that visceral adipose tissue decreased during treatment but returned to baseline after the drug was stopped, indicating the effect depends on ongoing exposure.

For me this lines up with what I’ve seen using GH secretagogues – you need regular dosing to keep the metabolic shifts, otherwise the body reverts quickly. The study only covers an HIV cohort, so we can’t assume the same durability or safety in healthy people using it off‑label for body recomposition, and it doesn’t touch on longer term risks beyond a year.

Has anyone tried cycling tesamorelin and noticed whether any fat loss persists off‑cycle, or does it all come back fast? Would love to hear real world experiences from those who’ve run it for a few months then taken a break.

Community discussion - research and educational context only. Not medical advice.