ResearchSafe

Adding GlyNAC alongside a KLOW-style stack, overkill or useful overlap?

Posted by tracker_jade in Protocols & Stacks - 1 points, 2 comments.

So I've been running a KLOW-adjacent protocol for about six weeks now for a stubborn tendon issue and anecdotally it's been going pretty well. Nothing dramatic but the nagging ache is noticeably less. I'm already doing BPC-157 and TB-500 as the core, with GHK-Cu a couple times a week.

I keep seeing people talk about GlyNAC for glutathione support and I'm wondering if it makes sense to layer that in while running a heavy healing stack. The GlyNAC profile says glycine and NAC at roughly 100 mg/kg each daily, split once or twice. That's a fair amount of powder. I've taken NAC solo before at 600 mg and honestly didn't notice much, but the combo with glycine apparently hits different.

My question is whether the glutathione boost actually complements what BPC and TB are doing on the inflammation side, or if it's just redundant. Like, is KPV already handling the NF-kB pathway enough that adding GlyNAC is piling on for no real benefit?

Also curious if anyone has dealt with the GI side effects at those higher NAC doses. 100 mg/kg for me would be somewhere around 6 grams of NAC daily, which seems like a lot compared to the standard 600 to 1800 mg range. Anyone actually run GlyNAC at the full protocol dose and tolerated it fine?

Comments

  • nerdy_nomad340: Honestly at 6g NAC daily I would be more worried about my stomach than excited about glutathione levels, no? I tried NAC at 1200mg for a few weeks and had that weird sour reflux thing, cant imagine doing 6x that. GlyNAC research is interesting but most of it is in older adults showing deficiency corrections, not really in people already doing heavy healing stacks. For me the inflammation side of BPC and TB seemed to work fine on its own without extra antioxidant support, but thats just how it f
  • benchpr_chemist: The stomach thing is real. I took NAC at 600mg on an empty stomach once and regretted it for hours. 6g sounds rough even split up. The research population gap is a fair point too. Most of the GlyNAC stuff is in older adults with measured glutathione deficiency. If you're not deficient, throwing more at it might not do much. Kinda like supplementing something your body already has enough of. I'd agree with starting low if you try it. Maybe 1-2g of each and see how your stomach handles it before

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