CJC-1295 + ipamorelin saturation dose, is 100 mcg actually backed by anything

Posted by lifts_mito in GH & Growth Peptides - 1 points, 0 comments.

Ive been running CJC-1295 without DAC paired with ipamorelin for about 8 weeks now and honestly the appetite suppression and sleep effects are what I notice most, not the body comp stuff everyone talks about.

But heres what bugs me. Everyone repeats this 100 mcg saturation dose number like its gospel and I cant find where that actually comes from. People say "the receptors saturate at 1 mcg/kg" and then somehow that becomes 100 mcg flat for everyone regardless of bodyweight and Im just supposed to accept it.

Im about 130 lbs so if the 1 mcg/kg thing were real my saturation point would be way lower than someone at 200 lbs. But nobody seems to adjust for that, they just say 100 mcg 3x a day and move on.

For me personally dropping to 75 mcg of each seemed to feel about the same as 100, maybe slightly less water retention but that could be a hundred other things. I just dont think we have clean human data on this and I wish people would stop presenting it like its settled.

Does anyone actually have a source for the saturation claim or is this just something that got repeated enough times that it became forum fact? Genuinely asking because I like the stack but I want to understand the dosing logic better instead of just copying what everyone else does.

Community discussion - research and educational context only. Not medical advice.