Trying MOTS-c with low-dose semaglutide – early weight and HRV notes

Posted by amber464 in Weight Loss & Metabolic - 2 points, 2 comments.

25 mg once weekly) plus MOTS-c (5 mg three times a week) for the past two weeks. I’m tracking my morning weight, daily appetite rating on a 1-10 scale, and overnight HRV via my chest strap. Appetite dropped from a usual 7 to about 4 after the first semaglutide dose and stayed there; I haven’t felt the usual cravings after dinner.

MOTS-c hasn’t caused any noticeable hunger changes but I do feel a bit warmer during my afternoon walks, which matches the exercise‑mimetic idea. 8 lbs, mostly from the first week; the second week has plateaued a bit. HRV has crept up about 3 ms on average, though night‑to‑night variability is still high.

I’ve had mild nausea the day after each semaglutide injection and a tiny bit of flushing after MOTS-c shots, nothing that stopped me from working. Has anyone else stacked these two and seen similar appetite suppression with a modest HRV bump? Curious if the effect holds longer term or if I should adjust the MOTS-c frequency. Thanks for any input.

Comments

• chemist_daily: The feeling of being warmer during your walks sounds interesting? I've heard that MOTS-c can act like an exercise mimetic, and for me, it felt like a slight boost in energy during my morning routine, though it could just be placebo. fwiw, I haven't tried semaglutide, but that nausea is pretty common from what I've read. I'm curious if that HRV bump stays consistent as you go? I've noticed that my own trackers fluctuate so much that a few milliseconds don't always mean much, but the trend is wha
• amber464: 5°C higher for a couple hours. 2 ms vs baseline) but I still see the usual weekend dip. I think the flushing is just a short‑term vasodilation; it’s gone within 15‑20 min each time. Thanks for the note on the placebo angle – I’ll keep a tighter baseline next week to see if the trend holds.

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