ResearchSafe

LL-37 for a slow-healing wound alongside BPC-157, anyone stacked them?

Posted by tracker_jade in Healing & Recovery - 6 points, 5 comments.

I have a stubborn wound on my shin that has been dragging on for weeks. Not diabetic or anything, just one of those injuries that refuses to close up fully. Anecdotally BPC-157 has helped me before with tendon stuff but I have not tried it for an open wound situation specifically.

I keep seeing LL-37 mentioned for wound healing and antimicrobial support. The idea of pairing it with BPC-157 seems logical on paper, one handling the infection side and the other handling tissue repair. But I have not found much real-world discussion of people actually doing both at the same time.

For those who have used LL-37, did you do it topically or subq? Did the local irritation people mention get bad enough to be a problem? And if you ran it with BPC-157, did you space the doses apart or just take them together?

Also curious if anyone noticed LL-37 doing anything BPC-157 alone did not. Trying to figure out if it is worth adding or if I should just stick with what I know has worked for me before.

Comments

  • labrat_vik: I tried LL-37 topically on a slow-healing scrape on my forearm last year, just a small amount mixed with sterile saline, and it seemed to help close it up faster than BPC-157 alone did for me, but honestly the BPC was already doing something so it is hard to say what the LL-37 actually contributed, could just be timing. The irritation was mild for me, kinda stingy for a minute after applying but nothing bad. I did them at the same time, no spacing, and it seemed fine. One thing though, a shin
  • tracker_jade: Thanks for the specifics on the topical route, that stingy-but-mild irritation is kinda what I expected. Good to hear you did them together without issues, that simplifies things. I hear you on getting it looked at. It is not infected, just slow, but fair point. What ratio of LL-37 to saline did you use? I have no reference point for topical concentration.
  • raj_j: Honestly the stinging thing is worth flagging more, I've heard a few folks say LL-37 topically can irritate more than expected depending on the wound bed. Glad it was mild for you though. And yeah, vik's right about getting that shin looked at. A wound just sitting there for weeks on the lower leg, that's a different animal than a forearm scrape. Blood flow down there ain't great even in healthy folks.
  • tracker_jade: Yeah the blood flow thing is fair, I probably underweighted that. Anecdotally my shin injuries always seem to take longer than stuff on my arms or hands, so that tracks. Did the people you heard from apply LL-37 directly to the wound bed or on intact skin around it? Wondering if dilution or application method makes a difference with the irritation.
  • curious_scientist: From what I've heard, direct application to the wound bed seemed to be the more common approach, imo. A couple people mentioned diluting it a bit with bacteriostatic water to take the sting down. Makes sense that intact skin around it would absorb less though. Did you notice any irritation when you tried it, or are you still figuring out the setup?

Community discussion - research and educational context only. Not medical advice.