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Running ipamorelin + CJC-1295 alongside a Wolverine stack, too much at once or fine?

Posted by fasted_scientist in Protocols & Stacks - 5 points, 7 comments.

So I've been on ipamorelin and CJC-1295 (without DAC) for about 8 weeks now, 100mcg each, three times a day on an empty stomach. Standard GH secretagogue protocol, nothing fancy. Seemed to help with sleep quality and recovery a fair bit, though I reckon some of that is just placebo and better sleep hygiene.

Anyway, I picked up a nagging rotator cuff thing about two weeks ago and I'm tempted to add BPC-157 and TB-500 on top, basically the Wolverine stack. BPC-157 at 500mcg daily and TB-500 at 2.5mg twice a week. My question is whether stacking all four at once is a bit daft or if it's generally fine since they're hitting different pathways.

The GH peptides are pulsing growth hormone, the BPC is doing local tissue repair stuff, TB-500 is more systemic. On paper they shouldn't interfere with each other but I can't find much actual data on combining secretagogues with healing peptides. Most of what I read is just anecdotal forum stuff (same as what I'm posting now, ngl).

Anyone here actually run both at the same time? Did you space the injections out or just pin everything together? Also curious if the GH pulse from the secretagogues would even add anything meaningful to tendon repair or if I'm just overcomplicating it.

Comments

  • curious_scientist: I ran something similar last year when a hamstring thing wouldn't quit. Had been on ipamorelin/CJC for sleep for maybe six weeks, added BPC and TB on top. Didn't notice any weird interaction tbh. Just felt like the BPC was doing its thing locally and the secretagogues kept doing what they were doing. I spaced them though, BPC in the morning, GH peptides at night. Seemed cleaner that way imo. Whether the GH pulse actually helped the tendon heal faster, hard to say. Could've been the BPC doing t
  • sleep_coastal: Anecdotally I did the same spacing when I ran BPC alongside a secretagogue stack and it felt cleaner too. Morning BPC, GH peptides before bed. No weird interaction that I noticed either. The one thing I'd watch is water retention. Both GH secretagogues and TB-500 can puff you up a bit and stacking them made that more obvious for me. Just something to keep an eye on.
  • raj_j: Spacing them out like that makes sense to me. I did something similar a while back, kept BPC and the GH stuff at opposite ends of the day. Honestly I think you're right that BPC does the heavy lifting on the tendon part, the secretagogues just kinda do their own thing in the background. For a few weeks I wouldn't overthink it.
  • fasted_scientist: Cheers for that, makes me feel a bit less daft about it. How long did you run the BPC for your tendon thing, and did you notice anything within the first week or did it take longer to kick in? Just trying to calibrate my expectations a bit since I've never used BPC before.
  • fasted_scientist: Cheers for that, good to hear someone else didn't get any weird interactions spacing them out like that. The water retention thing is a fair point I hadn't really thought about, ngl. I've not noticed much puffiness from the ipamorelin and CJC on their own but adding TB-500 into the mix could tip it over. Did you find the retention was mostly in your face or more general, and did it settle once you stopped the TB-500 or stick around for a bit?
  • fasted_scientist: Cheers for that, good to hear from someone who actually ran it. The spacing thing is interesting, I was planning to keep my three-times-a-day GH protocol and just slot BPC in separately. Did you drop one of your secretagogue doses when you moved to nights only, or were you already just doing once daily? The "BPC doing the heavy lifting" bit is exactly what I reckon too. Hard to separate variables without bloodwork or any proper marker. Ngl I'm mostly just hoping the combo doesn't blunt the GH p
  • curious_scientist: For me it was mostly general puffiness, like fingers and ankles more than face. Seemed to peak around week 2-3 of TB-500 and then gradually faded maybe a week or so after I stopped. Could've been other factors too though, I wasn't tracking it super carefully at the time. Imo if you're not already holding water from the secretagogues you'll probably notice the difference pretty quick once TB-500 kicks in.

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