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Semaglutide plateau at month 4, thinking about adding 5-Amino-1MQ

Posted by labrat_hank in Weight Loss & Metabolic - 10 points, 4 comments.

Been on semaglutide for about 16 weeks now. Titrated up slowly, 0.25 then 0.5 then 1.0, stayed at 1.0 for the last six weeks. First 10 weeks the scale moved steady, about 0.6 kg per week. Then it just stopped. Same calories, same activity, same everything. Weight has been flat for almost a month now.

I track resting heart rate and HRV every morning. RHR dropped nicely from around 68 to 61 over the first couple months, which seemed to track with the weight loss. But HRV has not improved much at all, maybe 2-3 ms on average. I expected more honestly?

Reading about 5-Amino-1MQ and the NNMT inhibition angle. The idea of boosting cellular energy expenditure on top of the appetite suppression from sema makes some sense to me on paper. Has anyone here actually combined the two and tracked anything objective? Weight, HRV, body composition, anything?

I am not talking about jumping into one of those multi-compound stacks. Just sema plus 5A1MQ, keeping it simple so I can actually tell what does what. My bloodwork is decent, fasting glucose in low 80s, lipids nothing alarming. But I want to be careful about stacking things that both affect insulin sensitivity.

Any real experiences out there?

Comments

  • midwest_scientist: I have not combined these two directly but I did run 5-Amino-1MQ on its own for about five weeks last year, 50mg daily oral. Honestly the appetite effect was noticeable for me, which surprised me because I expected more of an energy expenditure effect than anything. I did not track HRV at the time so I cannot speak to that part, which is annoying in hindsight. One thing I would watch with stacking on top of sema is that 5A1MQ seems to hit NAD metabolism in a way that can feel a bit stimulating.
  • labrat_hank: The appetite effect is interesting, I did not expect that from an NNMT inhibitor either. Makes me wonder if there is some overlap in pathway that would just pile on top of what sema is already doing. The jittery thing around week three is what I would want to watch for. My RHR is already down to 61 from 68, so if 5A1MQ pushes it lower or adds a stimulant effect on top, that could feel rough. Did the jitteriness show up in your resting heart rate at all, or was it more of a subjective thing you
  • curious_scientist: The jittery thing is interesting. I have seen a couple people mention that same week-three onset with 5A1MQ, which makes me wonder if it is a cumulative NAD thing rather than an acute effect. Like the body is adjusting to the shift in NAD availability and it takes a couple weeks to show up. Did you change anything when it settled, or did it just pass on its own?
  • labrat_hank: I have not actually started 5A1MQ yet, I was asking before jumping in. But the NAD cumulative theory you mentioned is a useful frame. If the jitteriness is a NAD shift rather than an acute stimulant effect, that would argue for keeping the dose low and riding it out rather than backing off. Did the people you saw mentioning the week-three onset stay on sema at the same time, or was 5A1MQ standalone?

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