Trying spermidine 5 mg daily for three months – what I noticed

Posted by midwest_scientist in Longevity & Anti-Aging - 6 points, 4 comments.

I started taking spermidine powder at about 5 mg each morning with breakfast roughly three months ago. Honestly I was curious after reading a bit about autophagy and thought it might be a simple add‑on to my usual routine. I did not change anything else dramatically – same diet, same training schedule, same sleep habits.

The first thing I noticed was a slight change in how I felt after lunch. Usually I get a small dip around 2 pm but it seemed less pronounced, almost like my energy stayed a bit more even through the afternoon. I also felt my recovery after evening runs was a touch quicker, less soreness the next day, though I cannot say if that is just placebo or maybe linked to better sleep quality.

Skin wise I did not see any dramatic wrinkle reduction but my complexion looked a bit more uniform, less dull in the mornings. No side effects besides a tiny bit of stomach gurgling the first week which went away.

Overall it feels like a low‑effort supplement that gave me subtle, noticeable shifts in daily energy and recovery. I plan to keep it for a bit longer and maybe track a few simple markers like fasting glucose just to see if anything shifts. Honestly it feels worth experimenting with for anyone interested in the autophagy angle.

Comments

• tracker_jade: I tried spermidine at 5 mg with breakfast for about eight weeks and noticed a similar mild lift in afternoon energy – the usual 2 pm slump felt a bit softer. Recovery after my evening bike rides seemed a tad quicker, though I can’t rule out placebo or just sleeping a bit deeper that period. My skin didn’t change much, but I did have less morning dullness. No stomach issues after the first few days. Curious if you’ve tracked any blood markers like fasting glucose or IGF‑1 while on it? Have you n
• midwest_scientist: Honestly I did not pull bloods specifically for the spermidine run, which I kind of regret now. I had a routine check around week 10 that included fasting glucose and it was within my normal range but I cannot compare it to before because I did not have a clean baseline. IGF-1 I did not test at all so no idea there. On the dose split, I only ever took it in the morning with breakfast. Never tried evening dosing. That afternoon energy thing was the main reason I kept it mornings, figured it made
• curious_scientist: I haven’t checked any blood work while on spermidine so I can’t speak to glucose or IGF‑1 changes. I just took the 5 mg all at once with breakfast and didn’t try splitting the dose. For me the afternoon energy lift felt real but could still be placebo or better sleep that period. No stomach upset after the first few days either. Curious if anyone’s seen labs shift noticeably?
• midwest_scientist: I'm glad you noticed the afternoon lift too, it's one of the few things that stuck with me. My own timeline was pretty consistent: 5 mg every morning with food, no splitting, and that tiny stomach gurgling faded after the first week. I'm curious if you've noticed any difference when you take it with versus without food, or if the texture of the powder matters for absorption. Also, have you tried cycling it, or just straight three months? I'm thinking of taking a short break after this run to se

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