ResearchSafe

TB-500 and elevated heart rate, anyone notice palpitations while running it?

Posted by tracker_jade in Safety & Side Effects - 9 points, 6 comments.

Been running TB-500 for about five weeks now for my shoulder, 2.5mg twice a week, and the past week or so I've been noticing my resting heart rate is up maybe 8-10 beats over my normal. Anecdotally I feel like my heart is just working harder at rest, especially in the evenings. Could totally be unrelated, stress, sleep, caffeine, whatever, but the timing is kinda suspicious since nothing else in my routine changed.

I've read some scattered stuff about TB-500 potentially affecting cardiac tissue since it's supposed to promote repair and angiogenesis, but I can't find anything concrete on whether that translates to actual heart rate changes in people. Wondering if anyone here has tracked their HR on TB-500 and noticed anything similar, or if you ran bloodwork and saw anything off.

I'm planning to pull some labs soon anyway, gonna check inflammatory markers and basic metabolic panel. Just curious if this is a known thing or if I'm just connecting dots that aren't there. If you stopped TB-500 and it resolved, that would be useful to hear too.

Comments

  • greg_codes: Ran tb-500 last year for a knee thing, 2mg twice weekly for about 6 weeks. My resting hr went up maybe 5-6 bpm around week 4, ngl i noticed it on my whoop data. Hrv dropped a bit too. I didn't change anything else so it was suspicious but i can't say it was definitely the tb-500? I stopped at 6 weeks anyway because the knee was sorted and within about 10 days resting hr came back to baseline. Could've been some mild systemic inflammation or just the body responding to the peptide, who knows. Th
  • curious_scientist: That whoop data tracking is smart, at least you had objective numbers to compare. The HRV drop alongside the HR bump is interesting, imo that does lean toward some kind of systemic inflammatory response rather than direct cardiac effects. The fact that it resolved within 10 days after stopping fits that too. Did you happen to notice any difference in how you felt subjectively during those weeks, like just generally more fatigued or wired?
  • curious_scientist: Yeah I saw something similar last year when I tried TB‑500 for a sore elbow – my resting HR crept up about 6 bpm after a few weeks and felt a bit more “pounding” at night. I stopped after eight weeks and it dropped back within a week or two. Could just be the body reacting to the repair signal, imo. No other changes in my routine.
  • tracker_jade: That's reassuring actually, the night-time pounding thing is exactly what I'm getting. Your 6 bpm bump is a little less than what I'm seeing but same direction. Did you change your dose at all before stopping, or just ran the same protocol the whole eight weeks? I'm wondering if dropping to once a week might settle it down before I decide whether to stop entirely.
  • tracker_jade: Yeah I did feel kinda wired more than fatigued, like that jittery feeling you get when you've had too much caffeine even though I hadn't. Hard to explain but it was more of a restless energy than exhaustion. Anecdotally it felt like my nervous system was just dialed up a notch. Sleep wasn't terrible but I'd wake up feeling like I never fully settled. Did you ever run anything alongside it or just TB-500 solo?
  • tracker_jade: That's actually really reassuring that you saw the same pattern right around week 4. The HRV drop is interesting too, I hadn't thought to check that but I should dig into my data and see if mine shifted. Did your HRV recover on the same timeline as the resting HR, like that 10-day window after stopping?

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