Fisetin senolytic hit days, anyone get GI upset at the 20 mg/kg range?

Posted by curious_scientist in Safety & Side Effects - 4 points, 4 comments.

Ran my first fisetin cycle last month. Two consecutive days at roughly 20 mg/kg, taken with a fat source since absorption is supposedly pretty poor on its own. By the second afternoon I had noticeable stomach cramping and loose stools. Not terrible but enough that I was second-guessing whether to finish the second dose.

I split it across the day thinking that would help. It kinda did but the GI stuff still crept in. I've seen people mention mild GI upset at high doses but I wasn't expecting it to be that uncomfortable. Could just be my own sensitivity to flavonoids in general, I react similarly to high-dose quercetin.

Curious if others here have run the hit-and-run protocol and dealt with the same thing. Did splitting doses more aggressively help? Or taking it with a heavier meal? I'm planning another cycle in a few months and wanna make it less miserable if possible.

Also wondering if the GI effects are any kind of signal that the senolytic action is actually happening, or if that's just me trying to rationalize the discomfort. Probably the latter imo. The long-term human data is pretty thin so I'm trying to keep expectations realistic and just track how I feel.

Comments

• kenji_runs: Yeah i ran a fisetin hit‑and‑run a while back at about 20 mg/kg split into two doses with olive oil. Day one was fine but by the evening of day two i got pretty bad cramping and had to run to the loo a few times. Cutting the dose into four smaller portions taken with a bigger meal seemed to blunt it a bit, though i still felt some rumble. I wonder if taking it with a bit more fibre or a probiotic helps – i’ve heard quercetin can irritate the gut too so maybe it’s just a flavonoid thing for some
• grinder_busy116: Yeah same here fisetin hit me hard on day two cramps and loose stools even split doses with oil. Cutting it into four smaller bites with a bigger meal helped a bit but still some rumble. Imo it’s just flavonoid gut irritation for some of us not a sign senolysis is kicking in.
• curious_scientist: Good to know I'm not the only one hitting that wall on day two. The four smaller bites idea sounds better than what I did, I only split into three. Gonna try that with a heavier meal next cycle. Did you take yours with like a full meal or just oil and a snack? Wondering if actual food volume matters more than just fat content for buffering the gut irritation.
• curious_scientist: The four-way split with a bigger meal sounds worth trying next time. I did three splits last time and it still got me by dose two, so maybe spreading it even thinner is the move. The fiber idea is interesting, imo that could go either way though, more fiber sometimes makes my cramping worse not better. Did you space the four doses every couple hours or just across meals?

Community discussion - research and educational context only. Not medical advice.