My 3‑month low‑dose rapamycin log – what I noticed

Posted by midwest_scientist in Longevity & Anti-Aging - 6 points, 4 comments.

I started taking rapamycin 4 mg once a week about three months ago, just to see how it felt alongside my usual spermidine and taurine routine. Honestly the first two weeks I didn’t notice much, maybe a tiny bit less afternoon fatigue but that could just be placebo. By week four I realised my recovery after heavy gym sessions seemed quicker – less soreness the next day and I felt ready to train again sooner.

Sleep stayed about the same, I still wake up once or twice but I fall back asleep fast. Around week six I noticed my skin looked a bit clearer, fewer small bumps on my forehead, though I’m not sure if that’s the rapamycin or just the extra water I’ve been drinking. 5 over the period.

Honestly I’m curious if anyone else has tried a similar low‑dose pulse and saw changes in markers like fasting glucose or lipids – I plan to get bloodwork soon to compare. If I continued I’d maybe try 5 mg weekly and keep tracking the same simple metrics. Just my own experience, nothing definitive.

Comments

• labrat_vik: I tried a similar weekly pulse for a while, though I went a bit higher than 4 mg, and for me it seemed to make my fasting glucose creep up a little bit. It was not a huge jump, but enough to make me pay attention, so you should definitely keep an eye on that when you get your bloodwork done. The skin thing is interesting because I didn't notice anything there, but I did feel like my joints were less cranky during my morning walks, though it could have just been a good month for the weather. If
• midwest_scientist: Thanks for the heads up on the glucose, that is exactly the kind of thing I want to catch early. Honestly I was kind of hoping rapamycin would be neutral or even slightly improve it, so hearing yours crept up makes me want to get that bloodwork done before I even think about going to 5 mg. Did your glucose go back to baseline after you stopped, or did it stay elevated? That would tell me a lot about whether it is a transient thing or something that sticks. The mouth sores thing is good to know,
• sleep_coastal: The glucose creep is a real thing to watch, anecdotally I noticed something similar when I was playing around with weekly dosing. Not dramatic but my fasting numbers nudged up maybe 5-7 points and took a few weeks after stopping to settle back down. Worth checking fasting insulin too if you can, not just glucose. The mouth sore thing is no joke either, had a couple of canker sores show up after bumping to 6mg once.
• midwest_scientist: I’ll add fasting insulin to my bloodwork panel. Did the glucose rise stay steady through your cycle or creep up later? I haven’t seen mouth sores at 4 mg yet, but I’ll watch for them if I go higher.

Community discussion - research and educational context only. Not medical advice.