Trying a low‑dose Superman + PE‑22‑28 combo for mood and recovery – need feedback

Posted by marcus617 in Protocols & Stacks - 2 points, 0 comments.

Hey folks, I’ve been running the classic Superman stack (CJC‑1295 100 µg + Ipamorelin 200 µg nightly plus 25 mg MK‑677 daily) for about six weeks now. I’m 49, train 4‑5 times a week, and have noticed marginal improvements in sleep quality and a bit less post‑gym soreness, but my mood has been a bit flat lately. After reading about PE‑22‑28’s TREK‑1 blockade and its rapid antidepressant signals in animal work, I decided to give it a cautious trial.

I reconstituted 1 mg in 1 ml bacteriostatic water, then took 20 µg subcutaneously every morning for two weeks, keeping the Superman doses unchanged. For me the morning PE‑22‑28 seemed to lift the mental fog a little and I felt a bit more motivated for the first training session of the day, though I can’t rule out placebo. No noticeable side effects yet, but I did get a mild light‑headed feeling after the first dose. I’m planning to continue the 20 µg for a total of four weeks and would love any thoughts on dosing, timing, or whether anyone has paired these two stacks before.

Community discussion - research and educational context only. Not medical advice.