ResearchSafe

GlyNAC alongside BPC-157/TB-500 stack, could the antioxidant side blunt healing signalling?

Posted by kenji_runs in Protocols & Stacks - 6 points, 4 comments.

Honestly been thinking about this a fair bit. I've been running oral BPC-157 at 500mcg daily with TB-500 2.5mg twice a week for a dodgy Achilles that wont quit, and its been going alright so far, seems like inflammation is down and i can jog again without wanting to cry.

But i also take GlyNAC most days, about 100mg/kg each of glycine and NAC split morning and evening, mostly for general oxidative stress stuff and sleep quality. The glycine honestly helps me sleep a bit i reckon.

My question is whether blunting oxidative stress with NAC could interfere with the repair signalling that BPC and TB are trying to upregulate. Like, reactive oxygen species are part of the normal healing cascade right, so if you suppress them too hard do you slow down the very thing you're trying to fix?

I cant find much on combining them directly. The KLOW stack page on here mentions KPV for inflammation but doesnt touch antioxidant interactions. Has anyone run a peptide healing stack alongside high-dose NAC or GlyNAC and noticed it helping or hindering? Or is this a non-issue in practice and i'm overthinking it?

Keen to hear if anyone's actually looked into this or just gut-feel'd it.

Comments

  • labrat_vik: 5 mg twice weekly for a sore elbow and I also take GlyNAC about 100 mg/kg each of glycine and NAC split morning and evening. For me the combo hasn’t seemed to slow the healing – pain dropped and I could start light lifting after a few weeks, which felt about the same as when I tried the peptides alone. I figure the ROS burst that kicks off repair is pretty short‑lived, so a steady antioxidant background doesn’t wipe it out completely, but that’s just my own experience and could be placebo. If y
  • greg_codes: Yeah nah i reckon vik's onto something with the short-lived ROS burst idea. The initial signalling wave after injury is minutes to hours, not a persistent thing. Steady-state NAC probably doesn't tamp that down much. I tracked hs-CRP during a similar stack and it dropped over 6 weeks which at least tells you systemic inflammation isn't staying elevated. Ngl though, CRP is pretty blunt for tracking tendon healing specifically. Wish there was an easy biomarker for that but there isn't really.
  • kenji_runs: Yeah the short-lived ROS burst thing makes sense actually, hadn't thought about it that way. If the signalling wave is minutes to hours then steady-state NAC probably isn't catching it. Cheers for that. The hs-CRP tracking is interesting though, did you notice any difference in how the tendon actually felt compared to baseline or was it mostly just the bloodwork looking better? Honestly CRP feels like it tells you nothing useful for tendons, like you said. Reckon the only real metric is just pa
  • kenji_runs: Honestly that makes sense about the ros burst being short lived. I was a bit worried i was basically fighting my own body, but if you saw the same progress on your elbow with the combo as you did with just peptides then that is a good sign. I reckon i will try to keep the glynac in for now since the sleep benefits are too good to bin. Did you notice any difference in the actual tissue feel or just the pain levels?

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