ResearchSafe

Rapamycin and lipid shifts, what are people actually seeing on bloodwork

Posted by student748 in Safety & Side Effects - 7 points, 7 comments.

Started rapamycin weekly about two months back, low dose, 3mg once a week. For what it is worth i feel fine on it, maybe slightly less sore after long runs but that could just be training cycle timing. Got my first bloods done since starting and my LDL came back a bit higher than my usual baseline, HDL roughly the same. Not dramatic but enough that i noticed.

I know the mouse data on rapamycin is mostly longevity stuff but i keep seeing mixed chatter about whether it nudges lipids in humans or if its just noise from diet or training load changing. My diet has been pretty consistent so i dont think thats it but i cant rule it out.

Keen to hear from anyone who has run rapamycin for a while and tracked lipids properly. Did you see a real shift or did it stay flat? And if it did move, did it settle back down over time or stick around? I'm planning to retest in another 6 weeks to see if its a trend or a one-off but figured id ask here first.

Also if anyone monitors fasting glucose or inflammatory markers alongside it id be keen to hear what you're tracking. My NP brain wants to order the full panel but trying to be sensible about it.

Comments

  • fasted_scientist: Ngl I’ve been on 3mg rapamycin once a week for about four months now and my lipids have been a bit all over the place. 3mmol/L after the first six weeks, then dropped back close to baseline on the next test, while HDL stayed steady. I can’t say for sure it’s the drug – my training load changed a bit and I had a few late nights that probably messed with my fasting state. I’m keeping a simple log of diet, sleep and workout intensity alongside the bloods so I can see if any pattern shows up. If yo
  • labrat_vik: I’ve been on 3mg once a week for about three months and my LDL crept up a little then settled back near where it started, HDL didn’t budge much for me either. I’ve noticed the swing lines up with weeks I ate heavier meals before the test, so I’m logging food timing now too. Good idea tracking those variables.
  • sleep_coastal: Yeah I saw a similar bump in LDL after my first test, then it settled. Anecdotally, keeping the same fasting time helped me spot real changes. Have you noticed any pattern with sleep quality?
  • student748: Chur thats reassuring to hear yours settled, gives me some hope the retest will look different. For what it is worth i havent noticed much change in sleep quality, maybe slightly deeper the night after dosing but could be coincidence. Good call on the fasting time though, mine was about 14 hours for this one so ill match that next time. Did your LDL take long to come back down or was it just the one follow-up test?
  • student748: Chur thats actually really helpful, sounds like a similar pattern to mine. The food timing thing is interesting, i didnt think about that at all. For what it is worth my test was done fasted but i had a pretty big feed the night before, like a proper carb-heavy dinner, so maybe thats part of it. Are you logging just the evening before or going back a couple days? Keen to know how granular youre going with it because if its just pre-test meal timing that could explain a fair bit of the noise.
  • student748: Chur thats actually really helpful, sounds like a similar pattern to what i'm seeing. The fact yours dropped back close to baseline on the second test is reassuring, makes me think my next draw might settle too. For what it is worth my training load has been fairly stable but i hadn't thought about fasting timing at all, my last bloods were first thing in the morning after an easy rest day so probably as clean as it gets. Are you logging the day before the blood draw too or just the week leadin
  • labrat_vik: I usually just look at the evening before and maybe lunch that same day, going back two or three days feels like overkill for LDL since the fasting window is what matters most for the actual draw. But honestly a big carb-heavy dinner the night before can absolutely shift things, I have seen my own LDL bounce around 10-15 points just from that, so it could explain a fair chunk of your bump. If you can, repeat the bloods after a more moderate dinner the night before and see if it settles back down

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