ResearchSafe

RU-58841 scalp irritation, anyone dealt with contact dermatitis from it

Posted by student748 in Safety & Side Effects - 4 points, 4 comments.

Been running RU-58841 topically for about 6 weeks now and the last week or so ive noticed my scalp getting proper itchy and flaky where i apply it. Not like normal dandruff, more like an actual reactive patch that stings a bit when i put the solution on.

For what it is worth i switched vehicles a couple weeks back from ethanol/keto to a premixed one so that could be the culprit rather than the RU itself. Just wondering if anyone else has hit this and whether it settled on its own or if you had to drop it entirely.

The stuff is supposed to be pretty clean systemically which is the whole appeal right, but i guess local irritation is still on the table. Read that contact dermatitis is listed as rare but "rare" doesnt mean much when its your own scalp burning.

Keen to hear if anyone changed their vehicle or added something to calm the skin down and kept going, or if that is just asking for trouble. Not keen on trading a hairline for a chronic skin issue, yeah nah.

Also curious if anyone has done any patch testing before starting, seems like that would have been the smart move in hindsight.

Comments

  • greg_codes: Yeah nah that sounds like the vehicle switch not the RU itself. I had a similar thing when i moved from a straight ethanol/PG mix to a premixed one, turned out it had some preservative or surfactant my scalp hated. Went back to my original vehicle and it settled within a week or so. Ngl i never did a proper patch test either, just powered through like an idiot. For me the irritation was the vehicle, not the compound, but that is just my own experience. Could be worth stopping for a few days, le
  • student748: Chur that actually makes me feel a bit better about it. The timing lines up heaps with the vehicle switch so thats probably where its at. For what it is worth i still have some of the old ethanol/keto stuff left so going back to that should be pretty straightforward. Did you find the irritated patch needed anything to settle it down or did you just leave it alone and let it sort itself out? Mine stings enough that im wondering if i should use something basic on it for a few days before restarti
  • curious_scientist: I’ve had similar flare‑ups when I switched to a pre‑mixed vehicle. Going back to my ethanol/PG mix cleared it in a few days. A quick patch test on the forearm saved me a lot of guesswork. Just my two cents.
  • student748: Chur thats actually super helpful, didnt think about doing a forearm patch test but that is dead obvious now you say it. Going back to the ethanol/PG mix cleared yours in a few days you reckon? Might just switch back and see if it settles before i write off the RU entirely. For what it is worth the premix felt easier but not worth a burning scalp. Did you reintroduce the RU straight away after switching back or give the skin a break first?

Community discussion - research and educational context only. Not medical advice.