Peptide bioregulators vs GH secretagogues, totally different world or same basics?

Posted by fasted_scientist in Beginner Questions - 6 points, 3 comments.

So I've been messing about with ipamorelin and CJC-1295 for a while now and I reckon I've got a decent grip on the GH peptide side of things. But I keep seeing people mention Khavinson bioregulators like Prostamax and I'm a bit lost on how they actually work compared to what I'm used to.

From what I can gather these aren't pushing a hormone pulse the way a GHRP does. They're signal peptides that supposedly regulate gene expression in specific tissues? That's a completely different mechanism to anything I've played with. The dosing looks weird too, like 1 to 2 capsules a day or short injectable courses, which is nothing like the mcg math I'm used to doing.

Ngl the lack of Western clinical data makes me a bit hesitant. With ipamorelin at least there's some real pharmacokinetic work behind it. Prostamax seems to be mostly Russian research and community anecdote.

Has anyone here actually tried bioregulators alongside GH peptides or are they best kept separate? And is the capsule form even worth bothering with or do you need to go injectable to get anything out of it? Just trying to figure out if this is a rabbit hole worth going down or if I should stick to what I know.

Comments

• labrat_vik: I’ve messed around with Prostamax capsules a couple of times while still running my usual ipamorelin/CJC‑1295 protocol, just to see if anything stuck, honestly I didn’t feel a clear change in recovery or sleep, could’ve been placebo or just my baseline noise, the oral dosing felt weirdly low compared to the mcg math I’m used to, I wonder if the gut breaks a lot of it down before it hits the tissue, injectable versions might bypass that but I haven’t tried them myself, if you’re curious keep a si
• fasted_scientist: That gut breakdown point makes total sense, I've noticed the same weird low dosing with the capsules. I've been thinking about running them off-cycle from my GH peptides just to isolate what's actually doing something, but haven't pulled the trigger yet. Cheers for the tip, I'll keep a simple log if I do give them a go.
• fasted_scientist: The oral bioavailability thing is spot on, that's exactly what puts me off the capsule route. Short peptide chains getting chewed up by digestive enzymes before they do anything useful seems like a real issue (though I've seen some claims about enteric coating helping, not sure how much I buy that). Running them off-cycle from your GH peptides is decent advice too, otherwise you're just guessing what's doing what. Did you log anything specific or just going by feel?

Community discussion - research and educational context only. Not medical advice.