ACE-031 vascular side effects, how worried should you be about the bleeding stuff?

Posted by kenji_runs in Safety & Side Effects - 1 points, 0 comments.

Been reading up on ACE-031 (/peptides/ace-031) and the whole myostatin/activin decoy receptor thing sounds brilliant in theory for muscle growth but the side effect profile is putting me off a bit honestly. Epistaxis, gum bleeding, telangiectasia, that all points to some proper vascular effects and i reckon thats not something to take lightly.

I know development got halted for DMD which kinda says something on its own. But i cant find much on whether the bleeding issues were dose-dependent or if they just happened regardless. Anyone here actually ran it and noticed any of that? Nose bleeds, weird bruising, anything like that?

Also keen to know if the telangiectasia is reversible once you stop. Seems like if youre messing with TGF-beta signalling enough to cause visible vascular changes thats a fairly big deal. I get that the muscle and bone density data looks promising but honestly the safety side feels underexplored for casual use outside clinical settings.

Anyone got bloodwork from before and after? Would be really useful to see if theres any clotting marker shifts or lipid changes.

Community discussion - research and educational context only. Not medical advice.