Fisetin senolytic hit days, anyone actually felt anything or is it silent

Posted by student748 in Longevity & Anti-Aging - 5 points, 4 comments.

Been reading the fisetin page on here (/peptides/fisetin) and keen to give the hit and run protocol a go. The idea of clearing out senescent cells sounds pretty compelling on paper but for what it is worth i cant find much from actual people saying they noticed anything tangible afterwards.

I get that senolytics might not produce an obvious "feel" the way something like rapamycin or nmn might. But surely someone out there has done a couple of rounds and noticed something, even just less general stiffness or better skin or whatever. Or is it genuinely just one of those things you do and hope its working silently in the background.

The dose around 20mg/kg on hit days is what the profile mentions. That seems like a fair bit to take in one go, has anyone had GI issues with it. I already had a rough time with NR on the stomach front so a bit wary of stacking another thing that might upset things.

Also wondering if people are cycling it with rapamycin at all or keeping them well apart. Seems like they both touch autophagy-ish pathways but different mechanisms. Too easy to just start throwing things together but i want to be a bit more thoughtful about it than that.

Keen to hear from anyone whos done a few rounds.

Comments

• fasted_scientist: I did two rounds of the hit protocol (roughly that 20mg/kg range spread over two days) and honestly felt nothing tangible either time. No stiffness reduction, no skin change, no energy shift. Could just be that it is genuinely silent, or could be it did nothing for me at all. Hard to say without markers. The GI bit though, ngl that was real for me. Mild cramping and loose stools both rounds, worse on an empty stomach. Taking it with food helped a fair bit. If you already had stomach trouble wit
• sleep_coastal: The GI thing tracks for me too. Anecdotally, I had the same mild cramping on my first round and switched to taking it with a decent amount of fat. Helped a lot. Second round was way smoother. I also kept rapamycin at least a week apart from the fisetin days, just seemed like common sense not to stack two things that can both hit the gut. Did you space yours out similar?
• student748: Chur thats actually super helpful, havent started yet so cant say on spacing but the fat tip is good to know. For what it is worth my NR stomach issues were the main thing putting me off so hearing the second round was smoother gives me a bit more confidence. Did you take the full 20mg/kg or dial it back a bit for round one?
• student748: Chur for the detailed writeup, thats exactly the kind of real-world feedback i was after. Bit deflating that you felt nothing either round but yeah nah i suspect thats just how senolytics roll, silent or nothing. The GI cramping and loose stools both rounds is what i was worried about. Good call on taking it with food, i will definitely do that. Did you spread the 20mg/kg across the two days or hit the full dose each day? Just trying to get the maths right on how you split it.

Community discussion - research and educational context only. Not medical advice.