Spermidine stacked with weekly rapamycin, too much autophagy or complementary

Posted by student748 in Longevity & Anti-Aging - 9 points, 4 comments.

For what it is worth i've been on low-dose rapamycin for about 3 months now, 5mg once weekly, and been reading heaps about spermidine as another autophagy inducer. The mechanism seems different enough that they might complement each other rather than just pile on, rapamycin hits mTORC1 directly and spermidine works through acetyltransferase inhibition right? But i genuinely dont know if running both on the same day is smart or if you'd want to space them out.

Has anyone here actually stacked these two together? Seemed like it could be a bit much for cellular clean-up signalling all at once, or could just be fine since they're hitting different pathways. I'm keen to try spermidine daily at the lower end, maybe 1-2mg, and keep the rapamycin weekly as is. Just my own thinking though, not sure if there's any real data on combining them in humans.

Also wondering if anyone noticed anything tangible from spermidine alone, like cognitive stuff or just feeling different. The research side of it looks interesting but i've learned from fisetin that "interesting preclinical data" doesnt always translate to anything you can actually feel. Chur for any input.

Comments

• sleep_coastal: I tried this combo for a few months last year. Anecdotally, I didn't feel any crash or over-cleansing, but I did space them out. I took the spermidine daily and just skipped it on my rapamycin day to be safe. As for feeling it, I honestly felt nothing on spermidine alone. It was a TOTAL ghost for me, similar to my experience with fisetin. I think the cognitive stuff is mostly just in the papers. If you do try it, just keep an eye on your blood sugar since rapamycin can mess with that. You shoul
• student748: Chur that's actually really helpful, skipping it on rapamycin day seems like a sensible approach for what it is worth. Interesting you felt nothing on spermidine, i had the same with fisetin, total silence. Did you track fasting glucose at all while on the combo? I've been meaning to get baseline bloods before adding anything new anyway. Might just start the spermidine on non-rapamycin days and see how it goes.
• greg_codes: Spacing it out like that makes sense, i'd probably do the same. The "ghost" thing matches what i've seen with spermidine, like you can't really feel autophagy happening can you? Did you track fasting glucose at all on the rapamycin days? Keen to know if you saw any actual movement there vs just going by feel.
• student748: Cheers for that, yeah nah i haven't tracked fasting glucose specifically on rapamycin days, just been going off how i feel which is obviously not the most rigorous approach. For what it is worth i've got some glucose strips sitting around from ages ago, might actually start checking on the morning after my weekly dose and compare to a non-dose day. Did you see any movement on yours when you were running it?

Community discussion - research and educational context only. Not medical advice.