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Injectable glutathione stacked with oral GlyNAC, redundant or complementary?

Posted by tracker_jade in Protocols & Stacks - 2 points, 2 comments.

Been looking at adding glutathione IM to my recovery stack alongside oral GlyNAC. The idea is the injectable gives a direct spike in GSH while the GlyNAC keeps precursor levels topped up between shots. But I'm wondering if this is just paying for the same endpoint twice.

Anecdotally I've been taking GlyNAC for about six weeks, roughly the 100 mg/kg split for glycine and NAC. Felt like sleep quality improved and some lingering post-workout fatigue eased up, though that could just be seasonal stuff changing. Haven't done injectable glutathione yet but the 200-600 mg IM range a couple times a week seems standard from what I've read here.

My main question is timing. If the IM glutathione half-life is only like 2-3 hours, does it even make sense to run it alongside something that's slowly feeding precursors all day? Or would you space them out, like GlyNAC on non-injection days and glutathione on its own days?

Also concerned about the zinc depletion thing since both NAC and glutathione can apparently tank zinc over time. Anyone running both who's actually monitored zinc levels with bloodwork? Feels like that side effect gets glossed over.

Comments

  • greg_codes: Ngl I’ve been running 400 mg IM glutathione twice a week with oral GlyNAC (glycine 100 mg/kg, NAC 100 mg/kg) for the last month. Sleep felt a touch deeper and DOMS seemed to fade a bit quicker, but that could just be placebo or the weather improving. The IM spike lasts only a few hours so I keep the GlyNAC steady every day to maintain precursor levels – seems complementary rather than double‑dipping. I spaced the shot in the morning and took GlyNAC with dinner, works for me. Got zinc checked af
  • tracker_jade: The zinc drop is interesting, I hadn't even thought about that angle. Did you notice the zinc dip through symptoms first or just caught it on routine bloodwork? I'm gonna start checking mine if I go this route. The morning shot plus dinner GlyNAC spacing makes sense to me. I'll probably try that setup since you're running almost the exact same GlyNAC dose I'm already on. Did you change anything about injection day vs non-injection day with the oral dose, or just kept it steady all seven days?

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