Dihexa 10 million times more potent than BDNF claim, is that actually meaningful or just marketing

Posted by student748 in Research & News - 1 points, 0 comments.

Was reading the nootropic god stack page here on researchsafe (/peptides/nootropic-god-stack) and the dihexa bit caught my eye. It says dihexa is a HGF/c-Met activator driving synapse formation, described as 10 million times more potent than BDNF at synapses. For what it is worth that number sets off alarm bells for me. Potency comparisons across totally different signalling pathways are a bit of a stretch to compare directly right? Like BDNF binds trkB receptors and dihexa works through HGF/c-Met, so saying one is X million times more potent than the other is comparing apples to oranges mechanistically.

I get that the preclinical data on dihexa looks interesting for cognitive stuff but i havent seen much in the way of human data and the half life listed is around 12h which seems long for something people describe as fast acting. Anyone here actually tried dihexa on its own rather than in a stack? Keen to hear whether the synaptogenesis claims translated to anything you actually noticed subjectively. The whole nootropic god stack combining four neurotrophic peptides at once seems like a lot to throw at your brain without knowing interactions. Chur for any input.

Community discussion - research and educational context only. Not medical advice.