Metformin B12 depletion, how many people here actually supplement and has it shown up on bloodwork

Posted by student748 in Longevity & Anti-Aging - 2 points, 0 comments.

Been reading up on metformin for longevity purposes and the B12 thing keeps coming up. For what it is worth the mechanism makes sense to me, something about it interfering with calcium-dependent absorption in the terminal ileum. But i'm keen to hear from people actually taking it whether they've seen B12 drop on labs or whether supplementing is just assumed necessary.

I'm considering low dose metformin alongside weekly rapamycin but stacking two things that both mess with cellular energy pathways feels like a lot to jump into at once. The AMPK activation overlap seems complementary on paper but i wonder if anyone here has done both and felt anything off, like fatigue or just flat energy.

Also curious if people split the dose or take it all at once. The GI stuff sounds rough based on what i've read, does it settle after a few weeks or is it ongoing. Not keen to trade gut comfort for theoretical longevity benefits if it's going to wreck my training days.

Anyone got real-world experience with this combo or metformin solo at the lower end of the range.

Community discussion - research and educational context only. Not medical advice.