Started ergothioneine alongside my rapamycin pulse, 4 weeks in

Posted by midwest_scientist in Longevity & Anti-Aging - 1 points, 0 comments.

So I have been taking ergothioneine for about four weeks now, 10 mg daily, on top of my weekly low-dose rapamycin. Honestly I did not expect much from it because my impression was just "expensive mushroom antioxidant" but the OCTN1 transporter thing got my attention. A compound the body specifically concentrates in stressed tissues is a bit more interesting than your average antioxidant supplement.

What I actually noticed so far: my skin seems less reactive, like normally after a long run I get this red flush on my cheeks that takes an hour to calm down, and the last couple weeks it fades faster. Could be the weather changing though, hard to say. Sleep quality felt the same. Energy maybe slightly more stable in the afternoon but that is so subjective.

The long tissue retention is appealing to me because I already pulse rapamycin weekly and did not want to add something I have to micro-manage. Taking it once a day and forgetting about it fits my style better.

Has anyone here run ergothioneine longer, like months? I am curious whether the effects build up or if it is just a slow background thing you never really feel. Also wondering if there is any reason to cycle it given the half-life is apparently weeks.

Community discussion - research and educational context only. Not medical advice.