Quercetin and CYP enzyme interactions, anyone actually looked into this properly?

Posted by kenji_runs in Safety & Side Effects - 2 points, 0 comments.

Been running the dasatinib + quercetin senolytic protocol a couple times now and honestly never thought much about the quercetin side beyond "it's a flavonoid, probably fine". But i was reading the /peptides/quercetin page and it flags CYP inhibition as a side effect and that kinda spooked me.

I'm on a few things that are probably metabolised through CYP pathways, nothing crazy but some standard stuff. Honestly i never considered that a "natural" supplement could mess with enzyme clearance like that. Does anyone know which specific CYP isoforms quercetin actually inhibits? And whether the pulsed senolytic dosing (like 1000mg for a few days) is enough to cause real interactions or if it's more of a chronic daily use concern?

Feels like people treat quercetin as totally benign because it's in onions and apples but the doses in these protocols are way beyond dietary intake. Reckon there's probably not much human pharmacokinetic data at these doses either.

If anyone's got proper references on this i'd be keen to see them, cheers. Not trying to be alarmist just want to understand the actual risk profile before i keep doing this.

Community discussion - research and educational context only. Not medical advice.