Trying spermidine daily with my weekly rapamycin pulse – 6 week notes

Posted by midwest_scientist in Longevity & Anti-Aging - 1 points, 0 comments.

I started taking spermidine about 1 mg each morning with breakfast while keeping my usual rapamycin pulse of 5 mg once a week on Sundays. Honestly I was curious if the two would feel redundant or if they’d add something different. The first two weeks I didn’t notice much besides a slightly lighter feeling in my stomach after meals, which could just be the spermidine doing its gut thing.

By week three I felt a bit more steady energy during my afternoon work slump, less of that usual dip after lunch. My sleep seemed a touch deeper, I woke up less often to turn over, though I still use my usual wind‑down routine. Skin wise I haven’t seen any obvious changes, but I’m not expecting miracles from spermidine alone.

I’m planning to keep this stack for another month and then take a short break to see if anything shifts when I stop. Honestly it feels like a gentle support rather than a sharp effect, which fits what I’ve read about autophagy inducers. If anyone has tried a similar combo I’d love to hear what you noticed.

Community discussion - research and educational context only. Not medical advice.