ResearchSafe

Thoughts on na semax and bdnf levels

Posted by runner777 in Research & News - 5 points, 2 comments.

I have been reading up on the stable versions of semax and selank (specifically /peptides/na-semax-amidate) and i reckon the shift toward these acetylated versions is spot on for anyone who actually tracks their data. I have always found the half life of the base versions a bit too short to be practical because you are constantly dosing and it messes with my recording of how it affects my focus.

For me the longer acting versions seemed to keep my mental clarity more consistent throughout the day but i noticed a weird trend where if i dosed too late it absolutely gutted my sleep quality (my wearable showed a massive drop in deep sleep) which makes me think the bdnf increase is quite potent. It could just be placebo or maybe just how my brain reacts to the dopaminergic shift but i felt way more wired than i do with plain selank. Do you lot think the increased stability actually leads to a more sustainable rise in neurotrophic factors or are we just trading convenience for a higher risk of overstimulation? I am keen to see if anyone else has tracked their sleep metrics while using the amidate versions.

Comments

  • optimizer_jenna: I actually had a similar experience with the acetylated versions. Tbh, the stability is definitely a benefit since the levels do not seem to crash so fast, but that window of overstimulation is real. For me, the mental clarity felt much more steady, but I also noticed that my heart rate stayed slightly higher during the evening. I am not sure if it is a direct result of the BDNF increase or if it is just the longer presence of the peptide in the system, but it definitely felt more intense than
  • fasted_scientist: Ngl I reckon it is more about the longer presence in your system than the BDNF. If it stays active longer, it makes sense that it would keep your heart rate up. I have not tracked deep sleep either, but I definitely noticed my resting heart rate was a bit higher on days I took it too late.

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