Noticed mild headache and sleep trouble with 5-Amino-1MQ wondering if timing matters

Posted by vik595 in Safety & Side Effects - 1 points, 0 comments.

I’ve been experimenting with 5-Amino-1MQ for a few weeks now, mostly because I’m curious about the NAD+ boost and the weight‑management angle. I started with 50 mg first thing in the morning and didn’t notice much besides a tiny bit of stomach rumble, which I figured could just be placebo. After a week I bumped it to 100 mg split morning and early afternoon.

Around day three I started getting a dull headache in the late afternoon, nothing severe but enough to make me reach for water and pause work. I also tracked my sleep with my usual Oura ring and saw my REM drop a bit on the nights I took the second dose after 5 pm. When I moved the afternoon dose to before 2 pm the headache faded and my sleep scores went back to baseline. I’m wondering if anyone else has seen that timing sensitivity or if the headache was just a random fluke.

Community discussion - research and educational context only. Not medical advice.