ResearchSafe

Noticed mild headache and sleep trouble with 5-Amino-1MQ wondering if timing matters

Posted by vik595 in Safety & Side Effects - 8 points, 4 comments.

I’ve been experimenting with 5-Amino-1MQ for a few weeks now, mostly because I’m curious about the NAD+ boost and the weight‑management angle. I started with 50 mg first thing in the morning and didn’t notice much besides a tiny bit of stomach rumble, which I figured could just be placebo. After a week I bumped it to 100 mg split morning and early afternoon.

Around day three I started getting a dull headache in the late afternoon, nothing severe but enough to make me reach for water and pause work. I also tracked my sleep with my usual Oura ring and saw my REM drop a bit on the nights I took the second dose after 5 pm. When I moved the afternoon dose to before 2 pm the headache faded and my sleep scores went back to baseline. I’m wondering if anyone else has seen that timing sensitivity or if the headache was just a random fluke.

Comments

  • aspiring_trailrun: I’ve been on 5 Amino‑1MQ for a month now and notice a pattern similar to yours. When I take the second dose after 5 pm the rest of the day feels a bit sluggish and my sleep quality dips, especially REM. Moving that dose to early afternoon or even 1  localizar makes the headache disappear and my Oura scores go back to normal. It probably has to do with how the compound shifts NAD+ and glucose metabolism; late‑day stimulation can bite into the body’s natural wind‑down. Have you tried a smaller do
  • vik595: Thanks for the reply, sounds like we’re on the same page. I moved the second dose to Debit 1 pm and the headache disappeared, just like your notes. I didn’t try a post‑workout slot yet, so that’s next. How long after your workout do you usually take it, and do you notice any change in your Oura HRV or REM then? ...
  • patient_ketogen: anecdotally i’ve been fiddling around too. i used to take 5‑mq in the afternoon, but the late‑night stir kept me wired and the REM was off. shifting the second dose to around 2‑3 pm helped the headache disappear and my sleep went back to normal. did you try a lighter evening dose or a post‑workout slot?
  • vik595: Thanks for the insight, I was just about to try a lighter evening dose. Do you keep the morning shot the same? Also, you mentioned 2‑3 pm was good; what dose did you use then? I’ll shift my split to that window and log REM again. I’ve been thinking about a post‑workout slot, did that help you keep the headache away?

Community discussion - research and educational context only. Not medical advice.