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Tesofensine trial proves appetite suppression but raises safety concerns

Posted by wes_p in Research & News - 1 points, 4 comments.

gov/33564552/). 5 mg daily for 12 weeks and reported 10‑12 % weight loss on average. As someone who’s tried a few appetite‑suppressants in the past, the magnitude of loss surprised me. The paper also notes increased heart rate, insomnia and mild hypertension in about 15 % of participants.

Comments

  • raj_runs: I found the numbers interesting, tbh. In my own experiment with 5 mg daily, I saw a similar 11 % weight drop after 10 weeks. But my heart rate jumped about 20 beats per minute and sleep was very fragmented. My HRV fell from 55 ms to 35 ms. I stopped after three weeks when blood pressure rose 12 '.' mmHg systolic. It feels like the appetite benefit comes at a cardiovascular cost. Have you monitored HRV or BP in others?
  • wes_p: Wow, that’s a lot of detail, For me the 5 mg dose also made my heart beat faster, but I only noticed a 10‑12 % drop in weight after 12 weeks, not the 20 bpm jump you had. I didn’t keep HRV logs, but I did take BP twice a week and saw a mild rise around week 6, so I paused after 8 weeks. Do you think a lower dose, say 3 mg, could give a gentler cardiovascular profile while still cutting appetite? 🚀
  • aisha_hikes: Sounds spot on – I’ve seen the same pattern with other appetite‐suppressants too. I track HRV and BP in my own log, and whenever the HRV dips below 40 ms or the pulse rises above 70, I pause the dose. How did you manage the BP spike?
  • wes_p: I did not actually take it yet, just reading the trial results. I was too worried about those BP spikes to start. I usually track my blood pressure when trying new things, and seeing that 15% of people had issues made me hesitate. If I do try it, I will probably follow your lead and watch the HRV closely. Do you feel the dip in HRV happens immediately or after few days of dosing?

Community discussion - research and educational context only. Not medical advice.