Increased Hunger With MK-677 (Superman Stack): How Bad Did It Get For You?

Posted by dailyrenee in Safety & Side Effects - 5 points, 4 comments.

Just checking if anyone else had the hunger from hell on MK-677. I’m talking about the kind that feels like a bottomless pit, not mild "I could eat" vibes. For me, it kicked in two days after starting, even though the rest of the Superman Stack (CJC-1295 and Ipamorelin) never did that solo.

Honestly, the appetite spike was so hard to control that I started tracking calories again, just to keep myself in check. (Didn’t help much tbh.) Bit of water retention too. My fasting glucose ticked up from 4.7 to around 5.2 mmol/L after two weeks, which wasn’t “pre-diabetes” or anything – just enough to make me pause and double-check the literature.

I found that splitting the MK-677 dose didn’t blunt the hunger for me. Lowering it to 12.5mg was a bit better, but not enough to keep cravings from wrecking my deficit.

Anyone else trying actual tricks to manage it? Any luck with timing doses before sleep or with bigger fibre meals? Or did you just muscle through?

Comments

• aspiring_trailrun: Yeah, that lines up with what I saw for myself. MK-677 was the one compound where the hunger felt almost mechanical, like my normal “I’m fine” signals were just switched off for a few hours. For me, taking it before bed helped a bit with not thinking about food all day, but it did not really remove the effect. Big fibre meals and protein earlier in the day seemed to blunt it slightly, although I could just be noticing the times I managed to stay disciplined 😎 The fasting glucose nudge is the
• dailyrenee: Yeah, that’s pretty much what I felt too, the “switched off” bit is bang on. Bedtime dosing made it less annoying during the day for me, but the hunger still showed up hard once I was awake. Protein and fibre helped a little, not enough to call it a fix. My fasting glucose only nudged from 4.7 to 5.2 mmol/L, but if it keeps climbing I’m parking the MK. Did you notice any water retention as well, or just the appetite?
• honest_cycles: Same here, the appetite was the main thing for me, but water retention was there a bit too, mostly face and rings feeling tighter. Bedtime dosing did make daytime hunger less obnoxious, although it did not remove it. I think that glucose change is small, but still worth watching, not something I would ignore...
• dailyrenee: Ja, that matches what I saw. Bedtime dosing was the one thing I hadn’t tried properly, only split dosing, and that was a waste of time for hunger, tbh. The face puffiness thing is also very familiar, my rings got snugger in about the first 10 days. I’m with you on the glucose bit. 4.7 to 5.2 mmol/L felt small, but enough to make me pay attention. Did bedtime dosing actually change your morning hunger, or just push the worst of it into the evening?

Community discussion - research and educational context only. Not medical advice.