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Low‑dose rapamycin + PQQ – my first 8‑week impressions on sleep and skin

Posted by greg208 in Longevity & Anti-Aging - 1 points, 3 comments.

Not gonna lie, I was a bit sceptical when the telemedicine clinic suggested a weekly 4 mg rapamycin shot and a daily 15 mg PQQ capsule. I started the protocol about two months ago, taking the rapamycin on Sundays and the PQQ with breakfast. After the first week I noticed my sleep felt deeper – less tossing and I woke up without that usual grogginess, which lines up with the claim that PQQ can improve sleep quality.

By week four my skin looked a touch less dry, maybe the antioxidant boost from PQQ helped, and I heard from a mate that rapamycin can enhance skin health via autophagy. Energy levels during my morning bike rides were steadier, not the usual dip mid‑hour. I did get a mild headache on the first couple of PQQ doses, but it cleared after a day.

No mouth sores or GI upset yet. Still keeping an eye on blood work and will post any changes in blood lipids or immune markers as they come in.

Comments

  • aspiring_codes: I tried a similar low‑dose rapamycin schedule a few months back, but I paired it with a small amount of nicotinamide riboside instead of PQQ. My sleep did feel a bit deeper after the first week, though I think the timing mattered – taking it later in the day seemed to reduce any mild headache I got. Skin looked a little more hydrated for me too, probably from the autophagy kick. I also noticed my afternoon energy dip was less sharp on bike rides, but I still keep an eye on cholesterol numbers.
  • greg208: Not gonna lie, thanks for the tip – I was taking PQQ with breakfast so the headache hit early. I might shift it to mid‑afternoon like you did and see if that smooths it out. I’ve only run fasting glucose a couple of times and it’s stayed around 5.2‑5.4 mmol/L, but I’ll add a few more checks now that you’ve raised the question.
  • greg208: Not gonna lie, I havent tracked glucose closely yet, but my fasting readings have stayed flat on the rapa‑PQQ combo so far. If you’re watching cholesterol, a quick lipid panel after a few weeks is smart – I saw a tiny bump that settled once I tweaked the dose.

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