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Adding Serrapeptase to my Wolverine stack – dosing timing and safety?

Posted by trevor_recovery in Protocols & Stacks - 5 points, 8 comments.

Hey everyone, ngl I’ve been on the classic Wolverine stack (BPC‑157 500 mcg daily and TB‑500 2.5 mg twice a week) for about eight weeks to help a lingering patellar tendon issue. I’ve noticed decent pain reduction and improved flexibility, but still get a bit of swelling after intense leg days.

I read that Serrapeptase can break down fibrin and reduce inflammation, so I’m considering adding it to the protocol. The usual recommendation is 120‑240 kSPU on an empty stomach, half‑life around 5 hours. My question is how to schedule it around the peptide injections to avoid any possible interaction or bleeding risk. Should I take Serrapeptase first thing in the morning, separate from the BPC‑157 injection, or maybe on non‑injection days? Also, has anyone noticed any GI upset when stacking Serrapeptase with these peptides? I plan to keep the BPC‑157 dose the same and keep TB‑500 at twice a week, just adding Serrapeptase daily.

Any thoughts on timing, dosage range, or red flags would be appreciated. Thanks!

Comments

  • amber464: I started adding Serrapeptase to my own BPC‑157/TB‑500 combo about a month ago after the same swelling hit me post‑leg day. I take the enzyme first thing at 6 am on an empty stomach, then do the BPC‑157 subcutaneous around 9 am and the TB‑500 on Mon/Thu evenings. With that spacing I haven’t seen any extra bruising or nosebleeds, and my gut feels fine – I’m careful to sip water with the enzyme and keep the dose at 150 kSPU. If you notice any stomach cramping, try splitting the dose into 2×75 kSPU
  • trevor_recovery: Thanks for the detail, ngl that schedule sounds doable. I’ll try the 6 am Serrapeptase at 150 kSPU and push the BPC‑157 to 9 am as you do. Splitting the dose if I get cramps is a good tip – I’ve had a bit of mild stomach rumble before, so I’ll keep the water sip habit. One quick question: have you noticed any change in the swelling timing after leg day now that you’ve added Serrapeptase?
  • liam_sleepnerd: Nice timeline, tbh. I’ve been doing the same 6 am serrapeptase then BPC‑157 mid‑morning and haven’t had any gut issues. I also split the 150 kSPU into two 75 kU doses around meals just in case. Have you noticed any change in the swelling pattern on leg‑day?
  • amber464: I haven’t tried the split‑dose yet, but I did notice the swelling dip a bit on leg‑day after moving serrapeptase to first thing in the AM. The tendinopathy feels a touch smoother around the workout window. Might be worth a try, just keep an eye on any stomach rumble and log the swelling scores.
  • trevor_recovery: Got it, I’ll move the serrapeptase to first thing in the morning and keep the BPC‑157 injection around lunch as before. I’ll start logging swelling on a 1‑10 scale like you suggested and watch for any stomach rumble. If I notice any increase in bruising or unusual soreness I’ll pull back. Thanks for the practical tip, will let you know how the morning timing works for me.
  • trevor_recovery: Thanks for the detail, ngl the 6 am serrapeptase then mid‑morning BPC‑157 sounds doable. I tried a single 120 kU dose before breakfast and didn’t notice any gut upset, but I’ll experiment with the split 75 kU around meals like you. The swelling has actually shifted – it’s less right after leg day but still shows up a day later, especially after heavy squats. Do you see a similar delayed pattern when you add serrapeptase?
  • hank_m: Yeah, after a couple weeks the post‑leg‑day puffiness seems to settle a few hours earlier – I still get a bit the night after a max squat, but the morning swelling’s way less noticeable, tbh. Might just be the enzyme helping clear fibrin, but could also be the timing shift.
  • trevor_recovery: Nice to hear it’s already making a difference for you. I’ve been timing my Serrapeptase about 90 minutes after the BPC‑157 injection, still on an empty stomach, and I mostly see the same pattern – less morning puff but a small residual swell after the heavy squats. Do you keep the enzyme dose same day as TB‑500 or push it to the other days? I’m curious if spreading it out changes anything.

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