ResearchSafe

Feedback on a 12‑week KLOW‑plus‑tirzepatide stack for tendon rehab and weight loss

Posted by trevor_recovery in Protocols & Stacks - 4 points, 4 comments.

I’ve been running a combined protocol for the last 8 weeks and want some eyes on the details before I push to week 12. My aim is to keep my Achilles tendon healing while also losing body fat for a beach competition.

I reconstitute BPC‑157 to 2 mg/ml (0.5 ml bacteriostatic water into a 1 ml vial) and inject 250 µg subcutaneously each morning. TB‑500 I keep at 5 mg/ml (2 ml bacteriostatic water into a 2 ml vial) and give 2 mg twice a week, spaced 48 h apart. GHK‑Cu I mix 200 µg in 0.5 ml sterile water and do 200 µg subcutaneously three times a week, on non‑TB‑500 days. KPV I reconstitute to 1 mg/ml and take 500 µg daily, same injection site as BPC‑157.

For weight loss I added compounded tirzepatide, 5 mg weekly, injected on the same day as my first TB‑500 dose. I started at 2.5 mg for two weeks, titrated up to 5 mg after a mild nausea episode that resolved with a light breakfast.

So far I’ve seen less tendon soreness after sprint sessions, and the scale is down about 3 kg with no loss of strength. I sometimes feel a slight flushing after GHK‑Cu, but no injection site issues.

Anyone spot potential interactions, dosing timing tweaks, or safety concerns with this mix? Especially regarding tirzepatide and the peptide anti‑inflammatory load. Thanks!

Comments

  • grace_sleepnerd: I’ve tried a similar BPC‑157/TB‑500 combo while recovering from a plantar‑fascia strain and added a GLP‑1 agonist for fat loss. For me the main thing was keeping the tirzepatide injection separate from the peptide shots – I found a morning‑fasted tirzepatide dose felt less nauseous and didn’t seem to blunt the mild anti‑inflammatory vibe from the BPC‑157. The GHK‑Cu flushing was also less when I put it on an empty stomach. 5 ml per site to avoid local irritation. How’s your sleep quality with t
  • trevor_recovery: Interesting, I never tried fasting the tirzepatide. I’ll move the 5 mg to first thing in the morning before any peptide injections and see if the nausea drops. My sleep has been decent – a couple of nights with slightly lighter REM, but overall I still wake rested. 5 ml per site as before; haven’t had irritation. Thanks for the tip, I’ll report back if the anti‑inflammatory feel changes.
  • amber464: I’ve also been spacing tirzepatide about an hour before breakfast, and my sleep hasn’t shifted noticeably – HRV stays around baseline and I still get 7‑7.5 h solid. The only hiccup was a slight dip in deep sleep the first few nights, but it normalized by week 2.
  • trevor_recovery: Thanks for the timing note, amber. I actually give tirzepatide right after my morning coffee, about 30 minutes before I eat, so I’ll try moving it an hour earlier like you do and see if my occasional light‑sleep dip smooths out. Do you notice any change in appetite cravings when you shift it that early?

Community discussion - research and educational context only. Not medical advice.