ResearchSafe

NR made my stomach weird, anyone else see that?

Posted by amber464 in Safety & Side Effects - 3 points, 4 comments.

I’ve been messing with NR on and off, usually 500 mg in the morning, and for me the main thing I noticed wasn’t some magic energy boost. It was GI weirdness. If I take it on an empty stomach, I sometimes get this mild nausea and a tight, off feeling in my gut for a couple hours. Could just be me, but it’s been repeatable enough that I quit pretending it was random.

What’s interesting is it seems way better with food, especially after eggs or yogurt. No dramatic flushing for me, just that stomach annoyance if I’m sloppy with timing. I track resting HR, sleep, and general mood, and honestly the numbers didn’t move much. Maybe a tiny bump in morning alertness, but that could easily be placebo and better sleep the night before.

I’m curious if anybody else has seen the same thing, or if you found a dose that doesn’t mess with your stomach. I’ve also wondered if stacking it with coffee is what makes it worse, because that combo feels kinda cursed some mornings.

Comments

  • early_scientist: Yeah, I got a similar thing with NR, especially if I tried it first thing in the morning before breakfast. For me, it wasnt nausea so much as this weird hollow feeling in my gut, almost like too much coffee but without the buzz. I also found that taking it with food, especially something with protein or fat like eggs, seemed to blunt that effect a lot. Im with you on not seeing any big changes in sleep or mood, though. Definitely not some night and day energy jump, at least for me. When I tried
  • amber464: Yep, that hollow feeling is a good way to put it, that’s basically what I meant by “tight, off.” Mine was most obvious on a near-empty stomach around 500 mg, and coffee on top of it was basically a nope. Eggs helped the most for me too, yogurt was second best. I’m not seeing much beyond maybe a tiny alertness bump either, and even that’s fuzzy. How far apart were you spacing NR and coffee when you noticed it, same time or within an hour?
  • aspiring_trailrun: Pretty much the same for me, coffee too close seemed to make the stomach stuff more obvious. If I left at least an hour and had food in me, it was usually fine. On an empty stomach with coffee, it felt a bit dodgy 😎
  • engineer_dan: Yep, same vibe here basically. NR on an empty stomach plus coffee felt pretty rough for me too, like my gut was complaining before anything else. With food, it’s way more tolerable. Could just be sensitivity, but that timing seems to matter a lot.

Community discussion - research and educational context only. Not medical advice.