Weekly low‑dose rapamycin gave me persistent mouth sores – how to mitigate?

Posted by amber464 in Safety & Side Effects - 1 points, 0 comments.

I’ve been on a 4 mg rapamycin shot once a week for the past six weeks, aiming for the autophagy boost people talk about. The first two doses were fine, but by the third injection I started waking up with a sore patch on the left side of my tongue and a mild burning feeling on the inner cheek. It wasn’t painful enough to skip a dose, but it was annoying enough that I started tracking it in my HRV and sleep logs. My HRV dropped a couple points the night after the sore appeared, and my sleep efficiency dipped by about 5 %.

I tried rinsing with a saline mouthwash and adding a probiotic lozenge before bed, but the irritation persisted for about three days after each dose and then faded. I haven’t noticed any GI upset or changes in my lipid panel yet, but the oral discomfort is the only side effect I’ve felt.

Has anyone else seen similar mouth irritation on low‑dose rapamycin? Any tips for prevention, like timing the injection later in the day, using a different carrier, or adding a specific oral rinse? Thanks.

Community discussion - research and educational context only. Not medical advice.