ResearchSafe

Scalp irritation and dryness with RU‑58841 – how to mitigate it?

Posted by holly763 in Safety & Side Effects - 1 points, 3 comments.

I’ve been using RU‑58841 for about six weeks, applying 80 mg in 1 mL ethanol‑based carrier every night to the crown and frontal areas. The first three days were fine, but by the end of week 1 I started noticing a mild tingling and a dry, flaky patch where I dabbed the solution. It isn’t painful, just itchy enough that I scratch a bit, and the skin looks a little lighter. I tried diluting the mix to 50 mg/mL and adding a few drops of aloe vera gel to the carrier, which seemed to reduce the itch after a couple of days. No redness or overt dermatitis, just that persistent dryness.

Has anyone else experienced similar irritation? Any tips on carrier choices or post‑application moisturizers that actually helped without compromising absorption? I’m trying to keep the regimen daily but want to avoid any long‑term skin damage. 🦵👀

Comments

  • hank_m: I've had the same vibe after a few weeks on ru‑58841, the ethanol does dry the scalp after a while and the tingling kinda feels like the scalp's adjusting, tbh. What helped me was swapping the pure ethanol for a 70 % propylene glycol/30 % ethanol mix – it still feels a bit stingy at first but the dryness drops off after a couple of days and the flake‑iness disappears. I also started a light layer of cerave moisturising cream right after the solution dries (so about 10‑15 min later) and that seem
  • holly763: Tbh that prop‑gly mix sounds promising – I’ve only tried ethanol with aloe so far. I’ll test a 70/30 blend tonight and wait the 10‑15 min before slapping on CeraVe like you said. Do you apply the cream to the whole scalp or just the dry patches? I’m curious if full‑scalp coverage changes the tingling at all. Thanks for the tip!
  • holly763: That sounds spot on, I’ve been thinking about swapping the carrier too. Do you use any particular brand of propylene glycol mix, or just a DIY blend? Also, have you noticed any difference in absorption speed with the cream on top? 🦵

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