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Apollo Stack: My 4‑Week Trial with Semaglutide, 5‑Amino‑1MQ, MOTS‑c, and Tesamorelin

Posted by liam_sleepnerd in Weight Loss & Metabolic - 4 points, 4 comments.

5 mg after two weeks as my appetite began to normalize. I paired that with 100 mg of 5‑Amino‑1MQ twice daily, 10 mg of MOTS‑c three times a week, and 2 mg a day of tesamorelin. My weight dropped 12 lb after 28 days, with about 7 lb of that coming from visceral fat on the DXA, and my HRV rose from 52 to 68 beats per minute over the same period.

The nausea was mild, just a 20‑minute post‑meal stir, so I kept the 5‑Amino‑1MQ consistent. However, I noticed a transient decrease in muscle fullness, which I broke with a brief resistance session twice a week. The stack’s appetite suppression was strong, so I cut meal portions by roughly 25 % without feeling deprived. 75 mg semag-i to see if the weight trend holds or plateaus.

Comments

  • raj353: I’ve tried semaglutide for weight loss myself and the nausea can be real, but the appetite hit was similar to what you’re seeing. Tbh the drop in muscle fullness is a thing, my body just lowers protein synthesis when carbs go down. I’d keep lifting heavy every other day and maybe add a small protein boost post‑workout to help. The HRV jump is cool; mine went from 48 to 65 on a similar stack. Did you notice any changes in energy or sleep? Those are the signals that tell whether the plateau is co
  • hank_m: Tbh i did feel more awake in the mornings, but nights got a bit lighter, more restless REM. After week 3 i noticed a mild dip in energy, but HRV still up. I kept the heavy lifts and added a protein shake post‑workout. How was it for you?
  • liam_sleepnerd: I didn’t notice a big dip in energy at week 3, but I did feel a little groggy in the late afternoon after the 5‑Amino‑1MQ before I hit the gym – I added a 15‑minute walk to keep the blood flowing, and the HRV stayed up. I didn’t spot any change in REM; my sleep overpower was steady 7‑8 hrs. I kept the same lifting volume as you – 3‑day split, 2‑implicit reps, no protein shake after the workout, just a normal whey before bed. Did the shake help you keep muscle fullness or recover after the lifts?
  • liam_sleepnerd: On the protein boost – I’ll add aain‑rich shake right after my two‑day lifts, about 25 g, to keep anabolic signaling up. I’ve noticed my energy stays steady early on but my sleep latency eases; I’m getting about 7–8 hrs per night, with an 10‑minute sweet‑spot récord after the first week of the stack. I’ll track those metrics as the 75 mg dose ramps up to see if the plateau creeps in.

Community discussion - research and educational context only. Not medical advice.