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BPC-157 after 6‑month Achilles tear – any advice on injection timing?

Posted by aspiring_trailrun in Healing & Recovery - 7 points, 10 comments.

I tore my Achilles tendon about six months ago after a trail run in the Lake District. I’ve been doing PT, range‑of‑motion drills, and a light cross‑train routine, but the swelling and stiffness still linger. A colleague suggested I try BPC‑157, and I’ve been injecting 500 mcg once daily in the thigh, close to the injury site, mixing it with a little անմ.

For the first two weeks I noticed a mild nausea from the injection, but the swelling went down noticeably, and my calf feels less achy after a 20‑minute walk. I’ve been timing the injection in the morning before breakfast and the second dose in the evening after my cardio session. I’m wondering if that’s the optimal schedule, or if I should space them out differently or inject ræða the exact site? Also, would adding a TB‑500 injection twice a week boost the healing, or would it just add unnecessary inflammation? Any practical tips on timing around the rehab programme would be great.

Comments

  • greg208: Not gonna lie the first couple weeks were a bit of a rollercoaster – that nausea keeps me honest but the calf pain eased faster than I expected. I’ve stuck to a morning shot before breakfast and an evening one after my cardio because I noticed a little more energy that way; switching to a oversees dose in the evening and an early‑afternoon shot hasn’t changed much for me, just feels a touch more chaotic. If you can, try to inject a bit later in the day when the blood flow to the leg peaks post‑w
  • aspiring_trailrun: Thanks for the insight. I’ll shift the evening shot to around 6 pm, right after my cardio, and see if the post‑workout blood flow helps reduce the irritation. I’ve also kept the morning dose at 9 am. As for TB‑500, I’ll pencil it in once a week for a month to gauge any added inflammation before committing. Did you notice any swelling changes with the later timing?
  • grace_sleepnerd: I’ve only tried BPC‑157 once for a nagging knee tweak after a long hike. I injected 250 mcg in the thigh each morning and felt a bit queasy the first few days, but the soreness eased after about a week. I didn’t notice much difference when I shifted the shot to evening, so I stuck with the AM dose because it fit my routine better. If you’re already seeing less swelling with your current schedule, maybe keep it as is and just watch how the nausea tracks. Adding TB‑500 could help some folks, but
  • greg208: Mate, I reckon AM dosing works for me too, nausea’s a pain, but if it reduces swelling, I’ll take it. Spot on you didn’t see timing differences; my knee’s still a bit grumpy either way. TB-500 sounds tempting, but I’m not gonna lie, stacking stuff without bloods feels risky. Cheers for the heads up!
  • liam_sleepnerd: Tbh Iিকা tried a post‑cardio shot too, about 1‑2 hours after my run, and the nausea dropped while the calf felt less tight. I also noticed a slight HRV bump around that window. Did you keep the same dose or tweak it after moving the timing?
  • hank_m: Tbh, i also had a mild case of BPC‑157 in my knee, used 250 mcg daily, and nausea in first couple days – i got it to settle by mid‑week, similar to yours, so maybe stick with AM. TB‑500 is a whole other ball‑game, i’d start super low (50‑100 µg) if i think the knee still jank, but be careful about stomach upset.
  • aspiring_trailrun: Thanks for the insight. I’ve been doing 500 mcg twice a day, so I’ll try dropping to a single morning dose and see if the swelling eases further. Regarding TB‑500, you suggest 50–100 µg; do you take it pre‑ or post‑meal and how do you track any gastric upset?
  • aspiring_trailrun: I kept the 500 mcg dose the same and moved the shot to about 1‑2 hrs after my run, following your example. Nausea did drop markedly and my calf feels noticeably looser after the walk. I’ve been logging HRV on an Apple Watch with the Health app – the spike was around 40‑45 ms, a bit higher than my baseline. Have you seen similar numbers, or did you use a different monitor?
  • aspiring_trailrun: Thanks for the quick feedback. I’ve been getting that same mild nausea after the first resolves and the swelling drops. Good to hear you see no timing difference – I’ll stick with AM and PM for now. About TB‑500, I’m tempted but you’re right on the bloodwork. I’d like to know which markers you’d monitor before stacking.
  • aspiring_trailrun: Sounds like we’re on the same page – the morning‑dose works for me too and the nausea has settled after a couple of weeks. I’ll stick with the 500 mcg daily in the thigh and watch the calf swelling. As for TB‑500, I’m thinking of waiting until the last four weeks of rehab before adding it, just to see if the extra injection triggers any redness or irritation. Did you notice any colour change at the site when you shifted the timing?

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