First FOXO4‑DRI Cycle – Injection Pain & Fatigue After 3 Weeks

Posted by greg208 in Longevity & Anti-Aging - 1 points, 0 comments.

Not gonna lie, I was prettyerialize when I saw the FOXO4‑DRI page and thought it sounded a bit too good to be true. After chatting with a few older mates on the forum, I decided to give a 3‑week course a shot – 10mg/kg, three times a week. The first dose was a bit of a shock.

I felt the injection site turn a bit red and warm, almost like a mild cellulitis reaction, but it settled after a day or so. It was the second week that I noticed a subtle drop in my energy – a dull fatigue that disappeared after a good night’s sleep. No major side effects so far, just a slight flu‑like buzz a couple of hours after each injection, which I think is the senolytic “clean‑up” in action.

I’m keeping my skin routine tight and logging my sleep – it’s been a bit shorter lately, around 6 hours, but quality seems to have dipped. I’m curious if anyone else has had the same post‑dose fatigue or noticed any changes in their skin elasticity or mood. Cheers for any tips or observations.

Community discussion - research and educational context only. Not medical advice.