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First Month on حصول 3mg Weekly Rapamycin – Sleep, Energy and Lipid Changes

Posted by greg208 in Longevity & Anti-Aging - 5 points, 5 comments.

I started a 3‑mg once‑weekly rapamycin dose three weeks ago, following the low‑dose pulse protocol that’s been floated around. I’ve been keeping a simple log of sleep, energy, and a quick lipid snapshot. Sleep has felt deeper; I go to bed around the same time but wake up less often.

Energy, oddly, has dipped a bit in the first week – a sort of “boot‑strap” fatigue – but by week three I’m ticking off my usual run without feeling dragged. 0 mmol/L, which worries me a bit since rapamycin can boost lipids. I’m not taking any statins, so I’m wondering if adding a short course of bergamot extract (500‑600 mg daily) might help keep the LDL in check.

Anyone else on this dosing schedule noticing similar lipid shifts or have a balancing strategy? Also, would a modest dose of spermidine help with the fatigue? Cheers for any insights!

Comments

  • liam_sleepnerd: I’ve been on the same 3‑mg weekly rapamycin pulse for two months now and my data look pretty similar to yours. Sleep latency dropped, I’m waking fewer times, and my HRV has actually gone up a touch, so I think the deeper sleep you’re noticing is real. The early fatigue I felt after the first dose was mild – just a “boot‑strap” phase – and it vanished by the second week when I ramped my protein and added a quick caffeine break pre‑ "run." Your LDL reading is a little odd; maybe you meant 0.?? Mm
  • greg208: Thanks for the heads‑up about the protein and caffeine tweak – will give that a go next cycle. The 0 mmol reading was probably a typo, I meant around 1.5 mmol, so an 18 % rise fits. How did you measure the LDL – a quick finger‑stick or lab test? Also, I’ll monitor the spermidine idea once the fatigue settles.
  • greg208: Sounds spot on – the sleep changes line up with what I’m feeling too. I did notice a boot‑strap drop in energy the first week, but re‑balancing protein and a short caffeine hit pre‑run helped. About the LDL typo – 0.?? Is what I meant, not 0. If bergamot’s been useful, curious how long you’ve seen the rise and what dose worked for you.
  • hank_m: Thanks greg, i’ve been watching my lipids too but haven’t hitliefer the same rise yet – if bergamot helped you it sounded solid, i’d love to hear how many weeks before you saw a change and what mg you stuck to, just for my own curiosity.
  • greg208: 4 mmol/L. 2 mmol/L – not back to baseline but a measurable drop. No further rise since then. If you’re not seeing the same shift, maybe try the higher end of the 500‑600 mg range or just give it a couple more weeks, the first 4‑6 weeks can be a bit rashy.

Community discussion - research and educational context only. Not medical advice.