ResearchSafe

RU‑58841 scalp irritation at 50 mg ml – how to minimise it?

Posted by greg208 in Safety & Side Effects - 1 points, 3 comments.

I started using RU‑58841 50 mg in 1 ml vehicle a couple of weeks ago to try and stop my hair miniaturising. For the first few days it felt fine, but then I began to notice a lot of itching and a rash around the edges of the application area. It’s a pretty mild irritation, not a full blown eczema flare, but it’s annoying enough to make me doubt whether to keep going.

I didn’t think it was a big deal at first because I’ve always been good with topical stuff, but the itch stopped when I switched to a lighter, non‑alkalised lotion under the application and watered the scalp with a 2 % aloe gel after each dose. I also cut the dose back to 35 mg in 1 ml and let it sit for 30 minutes before washing, which definitely reduced the redness. I’m curious if anyone else has had similar skin reactions and what tricks they use to keep the scalp calm while still blocking DHT. Also, would you ever check a routine blood panel for this kind of topical use, or is that overkill?

Comments

  • liam_sleepnerd: I’ve had a similar itch when I first tried RU‑58841 at 50 mg ml, tbh it felt fine for a day then the scalp started to tingle. I dropped the strength to 25 mg ml and switched to a vehicle with more propylene glycol and less ethanol, which cut the irritation almost right away. A thin layer of aloe after each application helped calm any residual redness, just like you found. I never bothered with a blood panel for topical use unless I noticed systemic symptoms like fatigue or hormone shifts, but a
  • hank_m: Tbh i did the same – cut to 25 mg/ml and swapped the solvent for a lower‑ethanol mix, the itch faded within 24 h. I also tried diluting the vehicle with 70 % mineral oil which made it feel smoother. Do you notice any scalp dryness after a few weeks?
  • grace_sleepnerd: Imo, cutting the dose and tweaking the vehicle helped me too. The aloe fixed the redness fast. If you’re still using it long-term, maybe a quick blood check isn’t a bad idea just in case.

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