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Trying Rapamycin: How it Changed My Energy and Sleep

Posted by greg208 in Longevity & Anti-Aging - 3 points, 6 comments.

I started the weekly 4 mg rapamycin cycle last month after a friend mentioned the immune‑boosting buzz. For me it was a bit of a gamble – I’m 42 and my energy dips around 3 pm every afternoon, plus my sleep is patchy since the age of 30. I took the pill on a Sunday night, as the protocol says, and slept through the whole 9 hours, waking up feeling more rested than I have in years.

The next day my leg pain from a long shift at the fire station cleared up quicker than usual, which I think is the anti‑inflammatory bit of the drug. I did get a mild mouth sore that lasted a few days, which kept me away from the pub for a bit. I’ve noticed my immune feel‑better, a small lift in my mood after the first few weeks. If you’re thinking about a low‑dose pulse, keep an eye on any soreness and just check how your body reacts – for me it’s been a net positive.

Comments

  • amber464: I actually did a similar 4 mg weekly run last winter and kept a tight log. After the first dose I checked HRV the next morning – it dipped a bit, but doubled back by Friday. 5 hours, and the mornings felt less groggy. The only kink was a mild jaw ache that lingered for a couple of days, similar to your mouth sore. If you’re on the pulse, I’d add a quick bloodwork check for liver enzymes just to be sure; I did that after week 3 and all was in range.
  • hank_m: Tbh i felt the same jaw ache, so i’m glad you mentioned it, amber464, it’s a common side‑effect early on, especially with a 4 mg dose, i’ve had a mild sore too, i’m planning a quick LFT week‑five just to be safe, have you noticed any heart rhythm shifts?
  • hank_m: Tbh it’s reassuring to hear the HRV bounce back – I saw that too early on, kinda like a quick dip then a rebound by mid‑week, so it felt normal, not a red flag, but I’d still keep an eye on it if I’m doing it every month. I’d also get a liver panel after the first few cycles, just to be safe, same as you. The jaw ache was a bit different but that’s the same ‘body‑reacting’ vibe we’re talking about.
  • greg208: Thanks for the heads‑up about the HRV dip and rebound – I haven’t tracked it yet, but I’ll start logging it next week to see if it mirrors what you saw. Will book a liver panel after the first cycle, that makes sense. My mouth sore was the main issue, not jaw pain, but I’ll keep an eye on any new aches and let you know.
  • greg208: I did feel that jaw ache and the mild mouth sore right after the first dose – so good you mentioned it. I’ll be doing an confrontation LFT around week‑five too, just in case. No odd heart rhythm has crossed my mind so far – my pulse stays steady, but I’ll keep a close eye on it. Will let you know if anything changes.
  • greg208: Great to hear yours mirrored mine – the mouth sore and jaw ache were the only red flags for me too.finance. I didn’t track HRV, but I’ll try a quick log next dose to see if there’s a dip. Good call on the liver check‑ins; I’m up on the next week but never done an enzyme panel yet – will get it done and see if it holds the line.

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