First week on 3 mg rapamycin weekly – what to expect?

Posted by grace_sleepnerd in Longevity & Anti-Aging - 4 points, 6 comments.

I just hit the one‑week mark on 3 mg rapamycin once a week. I’m 38, a software engineer, and this is my first pill for longevity. The pharmacist told me that the drug’s half‑life is about 62 hours, so it should stay in my system for a while.

I’ve been taking it after dinner, with a 500 mg dose of metformin in the morning to keep my glycogen high. The first day I woke up with a slight sore mouth, which I think is normal at low doses. No severe GI upset so far, but I’ve been noticing a mild improvement in my skin tightness, maybe the autophagy is kicking in.

I’m still monitoring my lipids because I read rapamycin can raise them. I’m keeping a log and plan to check my fasting glucose next week. Any experience with rapamycin + metformin combos?

Comments

• sarah_c: I’m a bit surprised you’re seeing skin tightness after just a week, but that could just be a mild placebo effect or natural skin changes – for sure not a proven rapamycin sign. I’ve tried rapamycin with metformin too, keeping doses low, and I did see a slight dip in fasting glucose but my lipids did trend a touch higher after a month, so I started a higher‑dose omega‑3 and started watching the LDL. Have you checked your cholesterol yet? And how’s the appetite? I’ve felt a little hungry lately.
• hank_m: Tbh i just got my cholesterol panel last week, the LDL was 4.6 mmol, a tad up the way you mentioned, so i splashed on 2 g omega‑3 and added a handful of avocados to my lunch, and i’ve noticed my appetite isn’t as gnarly as it was earlier. I’ll let you know how it holds up in a couple of weeks.
• hank_m: Tbh i just did a quick home test last week and LDL was up a bit but still in range, no big red flags yet – i’ll double‑check it in a month. Appetite? Stays about the same, maybe a little extra on the weekend when i’m cooking, but nothing dramatic. Will keep the logs and see how it settles.
• grace_sleepnerd: Thanks for the update. I saw a similar slight LDL bump after week one too, but my numbers stayed in the green. I’m still monitoring them and plan to check fasting glucose next week since I’m on metformin too. Did you notice any change in your appetite on the weekdays? I’ve kept my intake pretty steady, so it’ll help to see if the weekend spill‑over you mentioned shows up in the logs.
• grace_sleepnerd: Sounds good, hank_m. 4.6 mmol LDL is a bit up; I’ve seen similar after a month of rapamycin so far. 2 g omega‑3 and avocados sound solid, those are my go‑to fats with the metformin. I’ll hit the same kitchen tweak and track myદાન level next check. How’s the appetite change holding up? Any drop in cravings?
• grace_sleepnerd: I checked my lipids just yesterday – total 190, LDL 115, triglycerides 140. No spike yet, but I’ll re‑check in a month. Appetite’s been steady; no extra hunger so far. You mentioned 4 g of omega‑3 after lipids climbed, do you use fish oil or krill, and how long did you wait to see that LDL drop?

Community discussion - research and educational context only. Not medical advice.