Trying Orforglipron 30mg – My Appetite and Weight Loss Journey

Posted by liam_sleepnerd in Weight Loss & Metabolic - 3 points, 4 comments.

I started Orforglipron 30 mg once daily about placing in my noon routine two months ago after seeing the weight‑loss data. For me the biggest change was the steady drop in hunger, especially in the post‑workout window where I used to binge on carbs. I trailed my appetite with a 3‑point scale, and the numbers shifted from a 6/10 at 1 pm to a 3/10 by 3 pm after a week.

My HRV stayed steady, so I didn’t see the usual dip that comes with intense appetite suppression. The side‑effects have been mild; a light nausea the first two doses that settled by day four, and a diarrhea episode on day 10 that I handled with a dose of probiotic. I’m keeping a log of weight and waist circumference, and after a 12‑week stall with my old regimen the 30 mg dose has helped Houdini my plateau a bit, though I’m still testing if 45 mg could push my weight loss further.

Comments

• hank_m: Tbh i noticed a similar pattern with orforglipron weekten this year, the appetite cut was almost instant in the late afternoon, so i could skip the binging that used to feel like a forced craving, i was still 30 mg for a few weeks and then climbed to 45 mg after a couple of months of plateau. My gut did flare up early on too, about the nausea and a single diarrhea day, but i kept a probiotic in the bag and that sorted it out. I haven’t watched HRV so it’s hard to say vantagens, but i’ve seen a s
• early_scientist: Sounds like you’re seeing the same quick appetite hit. I kept the same dose a while, and when the nausea hit I also added a probiotic, my gut cleared up after a couple of days. Don’t try to bump the dose too high if you’re plateauing; maybe a size‑up can work, but see how the stomach reacts first. Also, any HRV trend you notice after the weight drop would be great to track.
• liam_sleepnerd: Thanks for the heads‑up. I’ve stuck with the 30 mg and am adding the same probiotic regimen you mentioned; it’s been easing the gut a bit. I’ll start logging HRV after the weight drop at week 4 to see if there’s a trend. Do you have a preferred strain or dose that worked best for you?
• liam_sleepnerd: That’s a pretty close match to what I’ve seen, appetite shut off in the late‑afternoon window and a quick drop in waist inches. I hit the 45 mg after a two‑month stall too, and the probiotic helped with the early nausea and the one‑day diarrhea. I kept an eye on HRV and didn’t see a dip, which is odd since I’d expect a flare. How did your energy feel after the doses up to 45 mg? And did you notice any changes in your sleep quality when-type?

Community discussion - research and educational context only. Not medical advice.