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Apollo Stack Experience: Appetite, Tolerance, and Early Fat Loss

Posted by liam_sleepnerd in Weight Loss & Metabolic - 1 points, 6 comments.

I started the Apollo stack early last month after a stubborn 8‑week plateau on semaglutide alone, fixin’ to see if the added 5‑Amino‑1MQ, MOTS‑c, and Tesamorelin would jump my metabolic rate. The first week was a whirlwind of nausea, a bit of injection site soreness, and my HRV dipping a few beats per minute, tbh a real hummer for anyone who tracks sleep and recovery. 25 mg once weekly, 5‑A1MQ at 100 mg twice daily, MOTS‑c at 10 mg thrice weekly, and Tesamorelin at 2 mg daily.

By week three the nausea eased, but I noticed a subtle loss of muscle tone if I didn't maintain a strength session; I doubled my protein that week and my muscle power stayed stable. At the end of week four my weight had dropped 4 lb and body fat, per my calipers, fell 2 %. 5 mg weekly, watching for GI rebound, and logging every dose to see how my appetite and sleep adjust. Anyone else on this stack?

Comments

  • hank_m: Tbh i’ve tried a version of that stack but only the tesamorelin part and i hit a lot of the same early jitters – nausea, injection soreness, a little drop in HRV that stuck around for a few days, so i kept a sleep log to see what happened, it was useful. I noticed the same muscle‑tone dip when i cut back on weight work, so i also upped protein to 2.2 g/kg, that helped keep the strength steady. I’m curious how the 5‑A1MQ dose plays in with the semaglutide – do you see any change in appetite or sa
  • sarah_c: FWIW,ığın my own run I didn’t notice a huge extra drop in food drive beyond the semaglutide. 5‑A1MQ seemed to help keep energy steady but didn’t fire extra satiety. It feels like it just smooths the jittery crash that can come after the first hop of the stack. You get a bit more “full” after meals with semaglutide anyway, so the extra 5‑A1MQ is more a feel‑good bonus than a appetite hack.
  • data_optimizer: I got the same jitters in the first week – really nauseous and the HRV dipped a bit too. 5‑A1MQ at 100 mg BID usually doesn't add any extra appetite hit for me. I still felt the semaglutide’s satiety pull, but the 5‑A1MQ just kept my energy up a bit. Do you notice any extra fullness after meals?
  • liam_sleepnerd: I felt Abu same jitters, HRV dipped aboutapplication 4 bpm in week one too, tbh. The double‑dose 5‑A1MQ didn’t make me feel fuller; I actually had the same “fullness” after meals as on semaglutide alone. Energy stayed up, though I noticed a slight lift in endurance during my Wednesday lifts. Are you seeing any lift in resting metabolic rate or just the same steady level?
  • liam_sleepnerd: Thanks for the heads‑up, Sarah. I’ve been seeing a mild appetite dip in the first week, but it settles after the nausea clears, no extra satiety spike beyond semaglutide. The 5‑A1MQ actually helped smooth the post‑dose crash; my HRV dipped a couple of BPM at first, then rebounded. What dose were you using and did you track any changes in strength or protein needs?
  • liam_sleepnerd: I noticed the appetite dip mainly in the first week, about 25‑30 % less on the usual 100 mg BID, then it settled back close to baseline by week two, so the 5‑A1MQ didn’t seem to add extra satiety beyond semaglutide. I logged my portions and felt two meals were “just enough,” but cravings didn’t stay low long enough to out‑shine the semaglutide effect. I’ll keep an eye on that after the dose tweak.

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