Sermorelin timing with a healing block, is bedtime still best?

Question

I am looking at a simple sermorelin run for recovery and sleep, and I want some feedback on timing. The profile here says 200 to 300 mcg once daily before bed, with a short half-life and natural GH pulsatility preserved, which is exactly why I am even considering it. My own thought is to keep it boring and start at 200 mcg at night for a few weeks, then judge sleep quality, morning feel, and whether I get any headache or flushing. For me, simpler tends to be better with peptides, because when you stack too many moving parts you never know what is doing what, fwiw. Has anyone here found bedtime actually makes a noticeable difference versus earlier dosing? I have also seen people pair it with more aggressive recovery stacks, but I am not sure that is smart if the goal is just sleep and tissue repair. I am in the Netherlands, so I would rather keep the protocol clean and easy to monitor. If you have a way you map out timing and cycle length without making it a circus, I would love to hear it?

formerdana · Accepted Answer

Ive only used sermorelin as a very simple bedtime style protocol, and for me that seemed the cleanest way to judge it. When I tried taking anything too close to training or in the day, it got messy and I could not tell if the better sleep was real or just because I was already nackered. Bedtime felt more logical with the GH pulse idea, but honestly the big thing I noticed was whether my sleep score and morning resting pulse stayed stable over 2 to 3 weeks, not one night. I would keep it boring like you said, 200 mcg, same time, no extra stack, then see if headache, flushing, or odd dreams show up. If you have any glucose issues or other meds, I would ask a doctor first.

hana791 · Answer

That is pretty much the answer I wanted, fwiw. The 2 to 3 week window makes sense, I was also thinking one night tells you nothing. I have only seen the short-longevity side of sermorelin in people, so bedtime still looks the cleanest to me. If you had any odd dreams, did they start right away or only after a few days?

early_recovery · Answer

yeah, that was pretty much my takeaway too, bedtime felt the least messy and easiest to read, and anecdotally if i moved it earlier in the day i just ended up second guessing everything. i’d also watch the morning resting pulse and how flat or wired sleep feels over a couple of weeks, because one decent night can mean nothing really, mate. which bit changed most for you, the sleep depth or just the next day recovery feel?

hana791 · Answer

That is exactly the bit I was trying to separate, fwiw. In my case it was more the next day recovery feel than deep sleep, at least in the first few days. Sleep felt a bit more settled, but I could just as well be biased. I have not run it long enough yet to be confident, maybe 10 days total. Morning pulse is a good shout, I have not been tracking that closely enough. I think I will keep it at bedtime and watch both for another two weeks.

Sermorelin timing with a healing block, is bedtime still best?

Comments