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MK‑677: How it Changed My Sleep and Appetite After 4 Months

Posted by nomad_tyler in General Discussion - 1 points, 4 comments.

I started MK‑677 on 1 March, 20 mg nightly, and after a few weeks my sleep felt deeper and I fell asleep quicker. The hunger arrives at dinner, but I keep it in check. I noticed a slight water retention in my ankles, which faded after two weeks.

My IGF‑1 trend chart shows a rise, but I know that reading is only a guide. I haven’t had any significant joint pain, which is good because many people report that. I do feel a bit lethargic sometimes after the dose, so I try to take it earlier in the evening.

The difference in my training recovery is noticeable – I hit an earlier peak in muscle growth, but I caution that this is only my own observation. I keep a simple log of sleep hours and workout performance. I don’t recommend dropping it without speaking to a professional. If anyone else has tried the same dose, I’d love to hear how you felt.

Comments

  • hank_m: Tbh i’ve been on MK‑677 for a few months too, 20 mg nightly, and i can relate to the sleep kick‑in, i felt the first night two days in, the REM seemed deeper and i fell asleep faster, but my appetite hit a low‑point around 7 pm and i had to eat a small protein snack to keep it down, the water retention was similar – ankles a little puffy after 12 hrs but it slid off after a week, i’ve logged sleep hours and muscle gains, i also noted a mild sluggishness the morning after if i didn’t hit the dose
  • nomad_tyler: I’ve done the same 20 mg night‑time dose starting 1 March. Sleep felt deeper after the first couple of nights, similar to your “two days in” comment. I also noticed my hunger peaking near dinner, so I keep a small protein snack handy. I haven’t split the dose yet – I just shift it a bit earlier in the evening to cut the morning sluggishness. Have you found any benefit in a split dose?
  • aspiring_trailrun: I’ve been on MK‑677 myself for about six weeks, 20 mg at night. The first couple of nights felt a bit sluggish, so I cut the dose back to 10 mg and moved it to around 8 pm. Sleep latency dropped quickly and I woke feeling more refreshed, similar to what you describe. I’ve noticed a moderate craving around dinner, but eating a protein‑rich meal seems to blunt the spike. Water retention is pretty common – I kept a diary and the oedema in my calves lasted a week or so before normalising. Have you
  • nomad_tyler: m. m. And the first‑half‑night fatigue eased. Your protein‑rich dinner trick sounds useful, did you notice the appetite spike lessening right after you ate? I’d like to know if the timing change changed your IGF‑1 trend or water retention period.

Community discussion - research and educational context only. Not medical advice.